National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-m920009

Testing Status of Thiophenol - M920009

 

CASRN: 108-98-5

Formula: C6-H6-S

Synonyms/Common Names

  • Benzenethiol
  • Phenyl mercaptan

Known Uses

Chemical intermediate for insecticides, fungicides, pharmaceuticals, polymers (HSDB 1992). Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

Chemical Properties

Toxicity Effects (HSDB)

Genetic Toxicology

  • Salmonella  (A41329)  Completed 
    •  Negative 

Organ Systems Toxicity

  • 14 weeks Continuous Breeding (Legacy) (Gavage)  (RACB94001)  Completed 
    • Citation: Reproductive Toxicity of Thiophenol (CAS #103-98-5) Administered by Gavage to Sprague-Dawley Rats
    • Male and Female Rats: Sprague Dawley
    • Dose: TASK 2: 0, 9, 18, 35 MG/KG TASK 4: 0, 35 MG/KG.
  • 6 to 15 GD Conventional Teratology (Gavage)  (TER92133)  Completed 
    • Citation: Final Report on the Developmental Toxicity of Thiophenol in Sprague-Dawley (CD) Rats
    • Citation: Final Report on the Developmental Toxicity of Thiophenol in Sprague-Dawley (CD) Rats
    • Female Rats: Sprague Dawley
    • Rats Maternal Positive 
    • Rats Fetal Positive 
    • Dose: 0, 20, 35, 50 MG/KG.
  • 6 to 19 GD Conventional Teratology (Gavage)  (TER92134)  Completed 
    • Citation: Final Report on the Developmental Toxicity of Thiophenol in New Zealand White Rabbits
    • Citation: Final Report on the Developmental Toxicity of Thiophenol in New Zealand White Rabbits
    • Female Rabbit: New Zealand White
    • Rabbits Maternal Inadequate 
    • Rabbits Fetal Negative 
    • Dose: REP I: 0, 10, 30, 50 MG/KG/DAY REP II: 0, 10, 30, 40 MG/KG/DAY.
  • 6 to 19 GD Teratology Pilot Studies (Gavage)  (TRP91038)  Completed 
    • Female Rabbit: New Zealand White
    • Dose: 0, .5, 1, 2, 5, 10, 20, 40, 50 MG/KG.
  • 6 to 15 GD Teratology Pilot Studies (Gavage)  (TRP92024)  Completed 
    • Female Rats: Sprague Dawley
    • Dose: 0, 1, 5, 10, 15, 20, 30, 40, 50, 60 MG/KG/DAY.
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.