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Testing Status of AZT + Methadone HCl (AIDS) M920012

 

CASRN: AZTMETHCOMB

Synonyms/Common Names

  • 3'-Azido-3'-deoxythymidine + Methadone Hydrochloride

Secondary:

  • 30516-87-1 - 3'-Azido-3'-deoxythymidine (AIDS)
  • 30516-87-1 - AZT transplacental carcinogenesis study
  • 1095-90-5 - Methadone hydrochloride

Known Uses

Aids therapeutic

Short-Term Toxicity

  • 13 weeks (Gavage)  (C92014)  Completed 
    • Mice: B6C3F1
    • Dose: AZT: 200, 400, OR 800 MG/KG/DAY WITH METHADONE HCL: 5, 15, OR 30 MG/KG/DAY.

Special Studies

  • Toxicokinetic Study (Gavage; Intravenous)  (S0305)  Completed 
    • Citation: Part of Short Term Toxicity Study C92014 & RACB STUDY 92023
    • Female Mice: B6C3F1; Female Mice: Swiss CD-1; Male Mice: B6C3F1; Female Mice: B6C3F1; Female Mice: Swiss CD-1
    • Dose: IV: AZT: 100 MG/KG METHADONE: 0 MG/KG & AZT: 0 MG/KG METHADONE: 2.5 ORAL: AZT: 100 METHADONE: 0 AZT: 200 METHADONE: 0 AZT: 400 METHADONE: 0 OR 15 AND AZT: 0 METHADONE: 2.5 AZT: 0 METHADONE: 7.5 AZT: 0 OR 400 METHADONE: 15 MG/KG chemtasks chem00207 & 208.

Organ Systems Toxicity

  • Repro/Dev Gen Tox (28-Day) (Gavage)  (RACB92023)  Completed 
    • Male and Female Mice: Swiss
    • Dose: AZT:0, 200, 400, 800 MG/KG/DAY; METHADONE: 0, 5, 15, 30 MG/KG/DAY.