National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-m920014

Testing Status of Polydimethylsiloxane (silicone) - M920014

 

CASRN: 9016-00-6

Related: ALSO CALLED POLYDIMETHYLSILOXANE RUBBER (63394-02-5)

Formula: (C2-H6-O-Si)x-

Synonyms/Common Names

  • Dimethicone 350
  • Poly(oxy(dimethylsilylene)) (9CI)(8CI)

Known Uses

Surgical implants; water-repellent; protective creams & lotions; lubricants/oils; component of waxes & polishes

Chemical Properties

Toxicity Effects (HSDB)

Organ Systems Toxicity

  • 180 day exposure Immunotoxicity (Intraperitoneal Injection)  (IMM89050)  Completed 
    • Citation: Immunotoxicity of Silicone in Female B6C3F1 Mice - 180-Day Exposure
    • Female Mice: B6C3F1
    • Dose: NEAT.
  • 10 day exposure Immunotoxicity (Intraperitoneal Injection)  (IMM89051)  Completed 
    • Citation: Immunotoxicity of Silicone in Female B6C3F1 Mice - 10 Day Exposure
    • Female Mice: B6C3F1
    • Dose: NEAT.
  • Immunotoxicity (Topical Application)  (IMM90006)  Completed 
    • Citation: Assessment of Contact Hypersensitivity to Polydimethylsiloxane Fluid in Female B6C3F1 Mice
    • Citation: NTP Summary Reports on Immunotoxicology Vol. 1, No. 1-15: Assessment of Contact Hypersensitivity to Polydimethylsiloxane Fluid in Female B6C3F1 Mice
    • Female Mice: B6C3F1
    • Mice Female Negative 
    • Dose: "NEAT".
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