Testing Status of Urethane + ethanol (combination) M920016

 

CASRN: URETHCOMB

Formula: C3-H7-N-O2 + C2-H6-O

Secondary:

  • 64-17-5 - Ethanol
  • 51-79-6 - Urethane

Known Uses

(Urethane) chemical intermediate; solubilizer for cosmetics and pesticides; (ethanol) solvent; in alcoholic beverages and manufacture of denatured alcohols; in gasohol; anti-freeze agent; chemical intermediate; in synthetic rubber, pharmaceuticals, disinfectants. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

Short-Term Toxicity

  • 13 weeks (Dosed-Water)  (C00602C)  Report Complete 
    • TOX-52 (NIH Number: 96-3937)  (Tox Peer Review 06/00/1995A )
      Toxicity Studies of Urethane in Drinking Water and Urethane in 5% Ethanol in F344/N Rats and B6C3F1 Mice (CASRN 51-79-6)
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R&M:(WITH 5% ETHANOLIN WATER)0.011, 0.033, 0.11, 0.33, OR 1.0 G/100 ML.

Long-Term Carcinogenicity

  • 2 years (Dosed-Water)  (C00602F)  Report Complete 
    • TR-510 (NIH Number: 04-4444)  (Peer Review Approval 09/05/2002A )
      Toxicology and Carcinogenesis Studies of Urethane + Ethanol (CASRNs 51-79-6 & 64-17-5) in F344/N Rats and B6C3F1 Mice (Drinking Water Studies)
    • Mice: B6C3F1/NCTR BR (C57BL/6N x C3H/HEN MTV-)
    • Carcinogenesis Results
      • Male Mice Clear Evidence 
      • Female Mice Clear Evidence 
    • Dose: 0, 10, 30, OR 90 PPM.

Genetic Toxicology

  • Micronucleus  (A23852)  Completed 
    • Mice: B6C3F1
    • Male Positive 
    • Female Positive