National Toxicology Program

National Toxicology Program

Testing Status of Ethyl vinyl ketone - M920019


CASRN: 1629-58-9

Formula: C5-H8-O

Synonyms/Common Names

  • EVK
  • 1-Penten-3-one
  • Propionylethylene
  • Vinyl ethyl ketone

Known Uses

Natural& synthetic flavoring substance in orange aqueous essence & oils for flavoring & aroma enhancement, especially of orange juice. Reagent/chemical intermediate in organic synthesis; starting materials to produce pharmaceutical intermediates. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 2 weeks (Inhalation)  (C92006)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R&M: 0, 4, 8 OR 16 PPM.
  • 13 weeks (Inhalation)  (C92006)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R&M: 0, 2, 4, OR 8 PPM.

Genetic Toxicology

  • Micronucleus  (A17802)  Completed 
    • Mice: B6C3F1
    • Male Negative 
  • Micronucleus  (A40627)  Completed 
    • Rats: Fischer 344
    • Male Negative 
  • Micronucleus  (A65262)  Completed 
    • Mice: B6C3F1
    • Male Negative 
    • Female Negative 
  • Salmonella  (A91243)  Completed 
    •  Positive 
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.