National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-m920022

Testing Status of Trimethoprim/sulfamethoxazole (commercial) - M920022

 

CASRN: 8064-90-2

Related: 738-70-5 (TRIMETHOPRIM); 723-46-6 (SULFAMETHOXAZOLE); TMP/SMX (MIXTURE)

Formula: C14-H18-N4-O3.C10-H11-N3-O3-S

Synonyms/Common Names

  • 4-amino-N-(5-Methyl-3-isoxazolyl)benzenesulfonamide mixt. with 5-[(3,4,5-trimethoxyphenyl)methyl]-2,4-pyrimidinediamine
  • Septra
  • TMP/SMX
  • Trimethoprim/sulfamethoxazole (AIDS)

Known Uses

Drug used extensively in treatment of urinary tract infections and pneumonia caused by pneumocystis carinii; potential for increased use in treatment of HIV-infected persons

Chemical Properties

Toxicity Effects (HSDB)

Genetic Toxicology

  • Micronucleus  (A93640)  Completed 
    • Mice: B6C3F1
    • Male Positive 
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.