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Testing Status of 2-Methylimidazole M920024

 

CASRN: 693-98-1

Formula: C4-H6-N2

Synonyms/Common Names

  • 1H-Imidazole, 2-methyl (9CI)
  • 2-Methylglyoxaline
  • 2-Ml

Known Uses

Used in the manufacture of pharmaceuticals, photographic & photothermographic chemicals, dyes, pigments, agricultural chemicals & rubber. Used in epoxy resin systems for semiconductor potting compounds and soldering masks. Component of polymers including epoxy resin pastes, acrylic rubber-fluororubber laminates, films, adhesives, textile finishes and epoxy silane coatings. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 2 weeks (Dosed-Feed)  (C92012)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R: 0, 78, 215, OR 645 MG/KG M: 0, 183, 500, OR 1500 MG/KG (0, 1200, 3300, OR 10000 PPM IN FEED) 5/SEX/SPECIES/GROUP.
  • 13 weeks (Dosed-Feed)  (C92012)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R&M: 0, 625, 1250, 2500, 5000, OR 10000 PPM IN FEED; 10/SEX/DOSE.

Long-Term Carcinogenicity

  • 2 years (Dosed-Feed)  (C92012B)  Completed 
    • TR-516 (NIH Number: 05-4456)  (Peer Review Approval 05/22/2003A )
      Toxicology and Carcinogenesis Studies of 2-Methylimidazole (CASRN 693-98-1) in F344/N Rats and B6C3F1 Mice (Feed Studies)
    • Rats: F344/N; Mice: B6C3F1/N
    • Carcinogenesis Results
      • Male Rats Some Evidence 
      • Female Rats Clear Evidence 
      • Male Mice Some Evidence 
      • Female Mice Some Evidence 
    • Dose: MR: 0, 300, 1000, OR 3000 PPM; FR: 0, 1000, 2500, OR 5000 PPM; M: 0, 625, 1250, OR 2500 PPM; 60/SEX/SPECIES/GROUP.

Special Studies

  • Absorption Disposition Metabolism Elimination (Gavage; Intravenous)  (S0331)  Completed 
    • Citation: Sanders JM, Griffin RJ, Burka LT, Matthews HB. Disposition of 2-methylimidazole in rats. J Toxicol Environ Health A. 1998 May 22;54(2):121-32.Pubmed Abstract
    • Male Rats: F344/N
    • Dose: 5, 50, 150 MG/KG ORAL; 5 MG/KG IV.
  • Toxicokinetic Study (Gavage; Intravenous)  (K02825)  Completed 
    • Rats: Fischer 344; Mice: B6C3F1; Rats: Fischer 344; Mice: B6C3F1

Genetic Toxicology

  • Micronucleus  (A05124)  Completed 
    • Mice: B6C3F1
    • Male Negative 
  • Micronucleus  (A69851)  Completed 
    • Mice: B6C3F1
    • Male Positive 
    • Female Positive 
  • Micronucleus  (A84932)  Completed 
    • Rats: Fischer 344
    • Male Negative 
  • Salmonella  (A28742)  Completed 
    •  Negative