Testing Status of alpha-Cyclodextrin M920029

 

CASRN: 10016-20-3

Known Uses

Capturing agent used in the food industry for confections and soft-centered candies) and in medicine

Chemical Properties

Toxicity Effects (HSDB)

Special Studies

  • Other (Gavage)  (S0433)  Completed 
    • Citation: Yuan J, Jameson CW, Goehl, TJ and Collins BJ. Molecular encapsulator: a novel vehicle for toxicology studies. Toxicology Methods. 1991;1(4):231-241.
    • Male Rats: F344/N
  • Other (Gavage)  (S0434)  Completed 
    • Citation: Yuan J, Jameson CW, Goehl TJ, Elwell MR, Leininger JR, Thompson MB, Corniffe G, Carlton T. Application of molecular encapsulation for toxicology studies: comparative toxicity of p-Chloro-alpha, alpha, alpha-trifluorotoluene in alpha-cyclodextrin vehicle versus corn oil vehicle in male and female Fischer 344 rats and B6C3F1 mice. Fundam Appl Toxicol. 1992 Apr;18(3):460-70.Pubmed Abstract
    • Male and Female Rats: F344/N; Male and Female Mice: B6C3F1
    • Dose: 97% PURE CTFT IN CORN OIL OR ALPHA CD FOR 14 DAYS. 10 (MICE ONLY), 50, 400 & 1000 MG/KG IN CORN OIL & 10, 50 & 400 MG/KG IN ALPHA-CD..
  • C. elegans  (S0934)  Completed 
    • C. elegans
    • Dose: feed:(0, 1, 1.3, 1.6, 2.0, 2.5, 3.2, 4.0, 5.0, 6.3, 7.9, 10) mM 05/05/05; repro:(0, .79, 1.0, 1.3, 1.6, 2.0, 2.5, 3.2, 4.0, 5.0, 6.3, 7.9) mM 09/03/04; growth:(0, 1, 1.3, 1.6, 2.0, 2.5, 3.2, 4.0, 5.0, 6.3, 7.9, 10) mM 10/22/05.

Organ Systems Toxicity

  • 6 to 16 GD Conventional Teratology (Dosed-Feed)  (TER92135)  Completed 
    • Citation: Final Report on the Developmental Toxicity of alpha-Cyclodextrin in Swiss (CD-1) Mice
    • Citation: Final Report on the Developmental Toxicity of alpha-Cyclodextrin in Swiss (CD-1) Mice
    • Female Mice: Swiss
    • Mice Maternal Positive 
    • Mice Fetal Negative 
    • Dose: 0, 5, 10, 20%.
  • 6 to 16 GD Conventional Teratology (Dosed-Feed)  (TER92136)  Completed 
    • Citation: Final Report on the Developmental Toxicity of Alpha-Cyclodextrin in Sprague-Dawley (CD) Rats
    • Citation: Final Report on the Developmental Toxicity of Alpha-Cyclodextrin in Sprague-Dawley (CD) Rats
    • Female Rats: Sprague Dawley
    • Rats Maternal Positive 
    • Rats Fetal Negative 
    • Dose: 0, 5, 10, 20%.