National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-m920032

Testing Status of Water disinfection byproducts (Bromodichloroacetic Acid) - M920032

 

CASRN: 71133-14-7

Formula: C2-H-Br-Cl2-O2

Synonyms/Common Names

  • Dichlorobromoacetic acid (Water disinfection byproducts)

Known Uses

Bromodichloroacetic acid is a water disinfectant byproduct. Naturally occurring bromides in the water participate in the formation of this compound. This chemical is formed after disinfection of water with halogenated oxidants, usually chlorine.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 2 weeks (Dosed-Water)  (C96014)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R&M: 0, 62.5, 125, 250, 500, or 1000 mg/l; 10/sex/species.
  • 13 weeks (Dosed-Water)  (C96014)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R&M: 0, 62.5, 125, 250, 500, or 1000 mg/l; 20/sex/species.

Long-Term Carcinogenicity

  • 2 years (Dosed-Water)  (C96014B)  Completed 
    • TR-583 (NIH Number: 16-5925)  (Peer Review Approval 05/22/2014A )
      Toxicology Studies of Bromodichloroacetic Acid (CASRN 71133-14-7) in F344/N Rats and B6C3F1/N Mice and Toxicology and Carcinogenesis Studies of Bromodichloroacetic Acid in F344/NTac Rats and B6C3F1/N Mice (Drinking Water Studies)
    • Rats: F344/NTac; Mice: B6C3F1/N
    • Carcinogenesis Results
      • Male Rats Clear Evidence 
      • Female Rats Clear Evidence NONE
      • Male Mice Clear Evidence NONE
      • Female Mice Clear Evidence NONE
    • Dose: R&M: 0, 250, 500, or 1000 mg/L; 50/sex/species/dose.
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.