National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-m920035

Testing Status of 3-Chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone(MX) - M920035

 

CASRN: 77439-76-0

Formula: C5-H3-Cl3-O3

Synonyms/Common Names

  • 2(5H)-Furanone, 3-chloro-4-dichloromethyl-5-hydroxy-
  • MX

Known Uses

By-product of water chlorination

Chemical Properties

Toxicity Effects (HSDB)

Nomination Background

Short-Term Toxicity

  • 2 weeks (Dosed-Water)  (C95012)  Completed 
    • Mice: B6C3F1
    • Dose: M: 0, 6.25, 12.5, 25, 50, OR 100 MG/L; 5/SEX/GROUP.

Special Studies

  • Absorption Disposition Metabolism Elimination (Gavage; Intravenous)  (S0659)  Completed 
    • Citation: Lebetkin EH, Chen LJ, Burka LT. Disposition of 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5h)-furanone (MX) in B6C3F1 mice and F344 rats. J Toxicol Environ Health A. 2002 Dec 27;65(24):2101-18.Pubmed Abstract
    • Female Rats: F344/N; Male and Female Mice: B6C3F1; Female Rats: F344/N; Male and Female Mice: B6C3F1
    • Dose: 0.2, 2.0, 20 mg/kg.
  • Toxicokinetic Study (Dosed-Feed)  (S0616)  Completed 
    • Mice: B6C3F1
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