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Testing Status of AZT + Isoniazid (AIDS Initiative) M930018

 

CASRN: AZTISONIAZID

Secondary:

  • 30516-87-1 - 3'-Azido-3'-deoxythymidine (AIDS)
  • 30516-87-1 - AZT transplacental carcinogenesis study
  • 54-85-3 - Isoniazid

Known Uses

Drug combination to be used as AIDS therapy

Short-Term Toxicity

  • 13 weeks (Gavage)  (C93001)  Completed 
    • Mice: B6C3F1
    • Dose: AZT: 100, 200, or 400 mg/kg/day; isoniazid: 50, 100, or 150 mg/kg/day.

Organ Systems Toxicity

  • 1 to 31 Repro/Dev Gen Tox (28-Day) (Gavage)  (RACB93150)  Completed 
    • NIH Number: 99-3941
      Citation: NIEHS Technical Report on the Reproductive, Developmental, and General Toxicity Studies of 3'-Azido-3'-dioxythymidine (AZT) and Isoniazid Combinations (CASRNs 30516-87-1 and 54-85-3) Administered by Gavage to Swiss (CD-1®) Mice
    • Male and Female Mice: Swiss CD-1
    • Dose: N/A; N/A; N/A; N/A.