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Testing Status of Malachite green M930019

 

CASRN: 569-64-2

Formula: C23-H25-N2.Cl

Synonyms/Common Names

  • Acryl Brilliant Green
  • Aizen Malachite Green
  • Aniline Green
  • Benzaldehyde Green
  • C.I. Basic Green 4
  • Malachite Green chloride
  • N-(4-((4-(Dimethylamino)phenyl)phenylmethylene)-2,5-cyclohexadiene-1-ylidene)-N-methyl-chloride

Known Uses

Antibacterial and antifungal agent, as a dye for cloth & leather, as an histological stain, as an intestinal antihelmintic, as a wound disinfectant. Considered the most effective agent for combatting fungal infections in aquatic species.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 28 days (Dosed-Feed)  (C93005B)  Completed 
    • Rats: F344/N; Mice: B6C3F1/NCTR BR (C57BL/6N x C3H/HEN MTV-)
  • 4 weeks (Dosed-Feed)  (C93005)  Completed 
    • Rats: F344/N; Mice: B6C3F1/NCTR BR (C57BL/6N x C3H/HEN MTV-)
    • Dose: 0, 25, 100, 300, 600 OR 1200 PPM.

Long-Term Carcinogenicity

  • 2 years (Dosed-Feed)  (C93005)  Completed 
    • TR-527 (NIH Number: 05-4463)  (Peer Review Approval 02/17/2004A )
      Toxicology and Carcinogenesis Studies of Malachite Green Chloride and Leucomalachite Green (CASRNs 569-64-2 and 129-73-7) in F344/N Rats and B6C3F1 Mice (Feed Studies)
    • Rats: F344/N; Mice: B6C3F1/NCTR BR (C57BL/6N x C3H/HEN MTV-)
    • Carcinogenesis Results
      • Female Rats Equivocal Evidence 
      • Female Mice No Evidence 
    • Dose: R: 0, 100, 300, OR 600 PPM M: 0, 100, 225, OR 450 PPM.

Genetic Toxicology

  • Micronucleus  (A06580)  Completed 
    • Rats: Fischer 344
    • Male Negative 
  • Micronucleus  (A82983)  Completed 
    • Mice: B6C3F1
    • Male Negative 
    • Female Negative 
  • Salmonella  (A90714)  Completed 
    •  Negative