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Testing Status of p-tert-Butylcatechol M930033


CASRN: 98-29-3

Formula: C10-H14-O2

Synonyms/Common Names

  • 1,2-Benzenediol, 4-(1,1-dimethylethyl)-
  • 1,2-Dihydroxy-4-tert-butylbenzene
  • Pyrocatechol, 4-tert-butyl-
  • TBC
  • 4-tert-Butyl-1,2-dihydroxybenzene

Known Uses

As an antioxidant in foods and cosmetics, stabilizer & polymerization inhibitor for styrene, butadiene, neoprene. Antiskinning additive, corrosion inhibitor, activator for insecticides, phenolic-type germicide, and chemical intermediate for organic synthesis & component used as shoe adhesive. Being considered as a replacement for BHT and BHA in foods. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 2 weeks (Dosed-Feed)  (C93011)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R&M: 0, 3125, 6250, 12500, 25000, OR 50000 PPM; 5/SEX/DOSE.
  • 13 weeks (Dosed-Feed)  (C93011B)  Completed 
    • TOX-70 (NIH Number: 00-4415)  (Tox Peer Review 03/11/2002A )
      Toxicity Studies of p-tert-Butylcatechol (CASRN 98-29-3) Administered in Feed to F344/N Rats and B6C3F1 Mice
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R&M: 0, 781, 1562, 3125, 6250, OR 12, 500 PPM; 10/SPECIES/GROUP.

Special Studies

  • Absorption Disposition Metabolism Elimination (Gavage; Intravenous; Topical Application)  (S0556)  Completed 
    • Male Rats: F344/N; Male Mice; Male Rats: F344/N; Male Mice; Male Rats: F344/N; Male Mice
    • Dose: IV:RAT 3MG/KG; DERMAL: RAT 0.6, 6.0 & 63MG/KG, GAV: RAT 300MG/KG.

Genetic Toxicology

  • Micronucleus  (A09151)  Completed 
    • Rats: Fischer 344
    • Male Negative 
  • Micronucleus  (A14992)  Completed 
    • Mice: B6C3F1
    • Male Negative 
    • Female Negative 
  • Salmonella  (A39963)  Completed 
    •  Negative