National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-m930034

Testing Status of Cyclohexene oxide - M930034

 

CASRN: 286-20-4

Formula: C6-H10-O

Synonyms/Common Names

  • Cyclohexane oxide
  • Cyclohexene epoxide
  • 1,2-Epoxycyclohexane
  • 7-Oxabicyclo(4.1.0)heptane
  • Tetramethyleneoxirane

Known Uses

Primarily as industrial raw material in organic synthesis used to stabilize various acrylic intermediates for pesticide, pharmaceutical, perfumery and dyestuff manufacture. As a monomer in photoreactive polymerization. Other potential pharmaceutical uses.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 4 weeks (Gavage)  (C93012B)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R&M: 0, 6.25, 12.5, 25, 50, OR 100 MG/KG; 5/SEX/SPECIES/DOSE.
  • 2 weeks (Gavage)  (C93012C)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: MALE RATS AND FEMALE MICE: 0, 250, 500, 1000, 2000 MG/KG; 5/SPECIES/GROUP.
  • 4 weeks (Topical Application)  (C93012)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R&M: 0, 3.75, 7.5, 15, 30, OR 60 MG/KG; 5/SEX/SPECIES/DOSE.

Special Studies

  • Absorption Disposition Metabolism Elimination (Gavage; Topical Application)  (S0572)  Completed 
    • Citation: Sauer JM, Bao J, Smith RL, McClure TD, Mayersohn M, Pillai U, Cunningham ML, Sipes IG. Absorption, disposition kinetics, and metabolic pathways of cyclohexene oxide in the male Fischer 344 rat and female B6C3F1 mouse. Drug Metab Dispos. 1997 Mar;25(3):371-8. Pubmed Abstract
    • Male and Female Rats: F344/N; Male and Female Mice: B6C3F1; Male and Female Rats: F344/N; Male and Female Mice: B6C3F1
  • Metabolism (Gavage)  (S0802)  Completed 
    • Citation: Bao J, Smith RL, Sauer JM, Pillai U, Sipes IG. Simultaneous determination of cyclohexene oxide and its metabolites in rat plasma and urine by gas chromatography. J Chromatogr B Biomed Sci Appl. 1997 Aug 15;696(1):59-68.Pubmed Abstract
    • Male Rats: F344/N
    • Dose: Urine samples from rats which received an oral dose (100 mg/kg) of CHO were incubated at 37 degrees C with beta-glucuronidase (2000 un-its/ml urine) type VII A from E. coli (Sigma, St. Louis, MO, USA)..
  • Metabolism (Gavage; Intravenous)  (S0803)  Completed 
    • Citation: Sauer JM, Bao J, Smith RL, McClure TD, Mayersohn M, Pillai U, Cunningham ML, Sipes IG. Absorption, disposition kinetics, and metabolic pathways of cyclohexene oxide in the male Fischer 344 rat and female B6C3F1 mouse. Drug Metab Dispos. 1997 Mar;25(3):371-8.Pubmed Abstract
    • Rats: F344/N; Female Mice: B6C3F1; Male Rats: F344/N
    • Dose: 50 mg/kg, 120 μCi/ml. [14C]CHO (10 and 100 mg/kg), four rats per dose and four mice per dose. All animals received ∼50 μCi/kg of the radiolabeled compound..

Genetic Toxicology

  • Micronucleus  (A13539)  Completed 
    • Rats: Fischer 344
    • Male Negative 
  • Salmonella  (A10205)  Completed 
    •  Positive 
  • Salmonella  (A18107)  Completed 
    •  Negative 
  • Salmonella  (A61059)  Completed 
    •  Positive 
  • Salmonella  (A66013)  Completed 
    •  Positive 
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.