National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-m930039

Testing Status of Dimethyl sulfate - M930039

 

CASRN: 77-78-1

Formula: C2-H6-O4-S

Synonyms/Common Names

  • Sulfuric acid, dimethyl ester

Known Uses

Solvent used in the manufacture of dyes, perfumes, & pharmaceuticals. Methylating & sulfating agent for agrichemicals, fabric softeners, and various intermediates. Formerly used as war gas.

Chemical Properties

Toxicity Effects (HSDB)

Organ Systems Toxicity

  • Dominant Lethal (Female) (Gavage)  (DLF070)  Completed 
    • Citation: Generoso, W.M., Shourbaji, A.G., Piegorsch, W.W., and Bishop, J.B. Developmental response of zygotes exposed to similar mutagens. Mutation Res. 250:439-446 (1991).
    • Female Mice: C3H X C57BL
    • Mice Female Negative 
  • Preimplantation Zygote Effects (Gavage)  (PZEF68)  Completed 
    • Citation: Generoso, W.M., Shourbaji, A.G., Piegorsch, W.W., and Bishop, J.B. Developmental response of zygotes exposed to similar mutagens. Mutation Res. 250:439-446 (1991).
    • Female Mice: C3H X C57BL
    • Mice Female Positive 
  • Total Reproductive Capacity (Dosed-Water)  (TRC98015)  Completed 
    • Citation: Bishop, JB, Morris, RW, Seely, JC, Hughes, LA, Cain, KT, Generoso, WM. Alterations in the Reproductive Patterns of Female Mice Exposed to Xenobiotics. Fund. and Appl. Tox. 40: 191-204 (1997).
    • Female Mice: B6C3F1
    • Mice Female  +, INTERVAL 3
    • +, INTERVAL 3
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