National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-m930040

Testing Status of Hycanthone - M930040

 

CASRN: 3105-97-3

Formula: C20-H24-N2-O2-S

Synonyms/Common Names

  • 1-((2-(Diethylamino)ethyl)amino)-4-(hydroxymethyl)-9H-thioxanthen-9-one
  • Lucanthone metabolite

Known Uses

Compound used to treat human schistosomiasis; clinical use sharply reduced; no longer available in the US.

Chemical Properties

Toxicity Effects (HSDB)

Organ Systems Toxicity

  • Dominant Lethal (Female) (Gavage)  (DLF072)  Completed 
    • Citation: Sudman, P.D. and Generoso, W.M. Female-specific mutagenic response of mice to hycanthone. Mutation Res. 246: 31-43 (1991).
    • Female Mice: B6C3F1
    • Mice Female Positive 
  • Dominant Lethal (Male)  (DLM071)  Completed 
    • Citation: Sudman, P.D. and Generoso, W.M. Female-specific mutagenic response of mice to hycanthone. Mutation Res. 246: 31-43 (1991).
    • Male Mice
    • Mice Male Negative 
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.