Testing Status of Thalidomide (AIDS Initiative) M930053

 

CASRN: 50-35-1

Formula: C13-H10-N2-O4

Synonyms/Common Names

  • alpha-N-Phthalyglutaramide
  • 1H-Isoindole-1,3(2H)-dione,1-(2,6-dioxo-3-piperidinyl)- (9CI)

Known Uses

A sedative withdrawn from the market due to its association with fetal abnormalities. It currently has several investigational uses including the treatment of leprosy, recurrent aphthosis of nonviral and nonfungal origin in HIV patients, and graft vs. Host disease and transplant rejection. [mesh 2/95]

Chemical Properties

Toxicity Effects (HSDB)

Organ Systems Toxicity

  • 28 days Immunotoxicity (Intraperitoneal Injection)  (IMM96006)  Completed 
    • Female Mice: B6C3F1
    • Dose: 0, 30, 100, OR 150 MG/KG/DAY.
  • 14 days Immunotoxicity (Gavage & Intraperitoneal Injection)  (IMM97011)  Completed 
    • Female Mice: B6C3F1
    • Dose: IP/IJ: 0, 3, 10, 30, 60, OR 100 MG/KG/DAY GAV: 0, 10, 30, 60, 100, OR 200 MG/KG/DAY.