National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-m930058

Testing Status of Tetralin - M930058

 

CASRN: 119-64-2

Related: DECALIN (91-17-8)

Formula: C10-H12

Synonyms/Common Names

  • Naphthalene 1,2,3,4-tetrahydride

Known Uses

Solvents in paints, waxes, and polishes derived from naphthalene. Insecticide. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

Chemical Properties

Toxicity Effects (HSDB)

Nomination Background

Short-Term Toxicity

  • 2 weeks (Inhalation)  (C93025)  Completed 
    • Rats: F344/N; Rats: NCI Black Reiter (NBR); Mice: B6C3F1
    • Dose: R&M: 0, 7.5, 15, 30, 60, OR 120 PPM; 5 SEX/SPECIES/GROUP.
  • 13 weeks (Inhalation)  (C93025)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R&M: 0, 7.5, 15, 30, 60, OR 120 PPM; R: 20/SEX/GROUP M: 20/SEX/GROUP MR: 5/GROUP RENAL TOX.

Long-Term Carcinogenicity

  • 2 years (Inhalation)  (C93025)  Report Complete 
    • TR-561 (NIH Number: 09-5902)  (Peer Review Approval 02/25/2009A )
      Toxicology and Carcinogenesis Studies of Tetralin (CASRN 119-64-2) in F344/N Rats and B6C3F1 Mice (Inhalation Studies)
    • Rats: F344/N; Mice: B6C3F1/N
    • Carcinogenesis Results
      • Male Rats Some Evidence 
      • Female Rats Some Evidence 
      • Male Mice No Evidence 
      • Female Mice Equivocal Evidence 
    • Dose: R&M: 0, 30, 60, OR 120 PPM; 50/SEX/SPECIES.

Genetic Toxicology

  • Micronucleus  (A94802)  Completed 
    • Mice: B6C3F1
    • Male Negative 
    • Female Negative 
  • Salmonella  (A43612)  Completed 
    •  Negative 
  • Salmonella  (G93058)  Completed 
    •  Negative 
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.