National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-m930060

Testing Status of 2,4-Hexadienal - M930060

 

CASRN: 142-83-6

Related: 2,4-DECADIENAL (25152-84-5)

Formula: C6-H8-O

Synonyms/Common Names

  • 2,4-Hexadienal, trans,trans-

Known Uses

Food additive and chemical intermediate. Naturally occurring in a variety of plant products. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 2 weeks (Gavage)  (C93023)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R&M: 0, 3, 9, 27, 80, OR 240 MG/KG; 5/SEX/SPECIES/GROUP.
  • 13 weeks (Gavage)  (C93023B)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R&M: 0, 7.5, 15, 30, 60, OR 120 MG/KG; 10/SEX/DOSE.

Long-Term Carcinogenicity

  • 2 years (Gavage)  (C93023B)  Report Complete 
    • TR-509 (NIH Number: 04-4443)  (Peer Review Approval 10/18/2001A )
      Toxicology and Carcinogenesis Studies of 2,4-Hexadienal (89% trans,trans Isomer, CASRN 142-83-6; 11% cis,trans Isomer in F344/N Rats and B6C3F1 Mice (Gavage Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Clear Evidence 
      • Female Rats Clear Evidence 
      • Male Mice Clear Evidence 
      • Female Mice Clear Evidence 
    • Dose: R: 0, 22.5, 45, OR 90 MG/KG M: 0, 30, 60, OR 120 MG/KG.

Special Studies

  • Mechanisms (Gavage)  (S0836)  Completed 
    • Male Rats: F344/N

Genetic Toxicology

  • Micronucleus  (A11915)  Completed 
    • Rats: Fischer 344
    • Male Equivocal 
  • Micronucleus  (A53565)  Completed 
    • Mice: B6C3F1
    • Male Negative 
    • Female Negative 
  • Micronucleus  (A84857)  Completed 
    • Mice: B6C3F1
    • Male Equivocal 
  • Salmonella  (A46849)  Completed 
    •  Positive 
  • Salmonella  (A98429)  Completed 
    •  Positive 
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.