National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-m930061

Testing Status of 2,4-Decadienal - M930061

 

CASRN: 25152-84-5

Related: 2,4-HEXADIENAL (142-83-6)

Formula: C10-H16-O

Synonyms/Common Names

  • 2,4-Decadienal, trans,trans-

Known Uses

Synthetic flavoring and fragrance material; also evaluated as a corrosion inhibitor for steel in oil field operations. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

Chemical Properties

Toxicity Effects (HSDB)

Nomination Background

Short-Term Toxicity

  • 2 weeks (Gavage)  (C93022)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R&M: 0, 45, 133, 400, 1200, OR 3600 MG/KG; 5/SEX/SPECIES/GROUP.
  • 13 weeks (Gavage)  (C93022B)  Completed 
    • TOX-76 (NIH Number: 11-5969)  (Tox Peer Review 05/01/2008A )
      Toxicity Studies of 2,4-Decadienal (CASRN 25152-84-5) Administered by Gavage to F344/N Rats and B6C3F1 Mice
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R&M: 0, 50, 100, 200, 400, OR 800 MG/KG; 10/SEX/DOSE.

Genetic Toxicology

  • Micronucleus  (A49292)  Completed 
    • Rats: Fischer 344
    • Male Positive (Nonstandard Protocol) 
  • Micronucleus  (A67791)  Completed 
    • Mice: B6C3F1
    • Male Equivocal 
  • Micronucleus  (A74886)  Completed 
    • Mice: B6C3F1
    • Male Negative 
    • Female Negative 
  • Salmonella  (A30973)  Completed 
    •  Negative 
  • Salmonella  (A75903)  Completed 
    •  Negative 
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.