National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-m930066

Testing Status of Gemfibrozil - M930066

 

CASRN: 25812-30-0

Related: PEROXISOME PROJECT (GEMFIBROZIL)

Formula: C15-H22-O3

Synonyms/Common Names

  • 5-(2,5-dimethylphenoxy)-2,2-dimethyl pentanoic acid

Known Uses

Serum lipid regulating agent (antohyperlipoproteinemic)

Chemical Properties

Toxicity Effects (HSDB)

Special Studies

  • Toxicokinetic Study (Gavage; Intravenous)  (S0541)  Completed 
    • Citation: Toxicokinetic Study Report. The Toxicokinetics of Gemfibrozil. The Toxicokinetics of Gemfibrozil when Administered in Feed to Male Wistar Furth Rats, Syrian Hamsters and B6C3F1 Mice. The Toxicokinetics of Gemfibrozil in Male Sprague Dawley Rats, Syrian Hamsters and B6C3F1. August 29, 1995.
    • Male Rats: Sprague Dawley; Male Mice: B6C3F1; Male Hamsters: Syrian Golden; Male Rats: Sprague Dawley; Male Mice: B6C3F1; Male Hamsters: Syrian Golden
    • Dose: PRELM MICE IV: 16.6 MG/KG PO: 16.6,2124.8 MG/KG FEED: 200,16000 PPM; PRELM RAT IV: 4.29 MG/KG PO: 4.29,685.7 MG/KG FEED: 100,16000 PPM; PRELM HAMSTER IV: 15 MG/KG PO: 30,1000 MG/KG FEED: 1500,12000 PPM (2.1 & 107.1 MG/KG). SA MICE IV: 8.4 MG/KG PO: 8.4,16.6,49.8 MG/KG; SA RAT IV: 4.29 PO: 4.29,50,100 MG/KG; SA HAMSTER IV: 15 MG/KG PO: 8,15,30 MG/KG..
  • Toxicokinetic Study (Dosed-Feed)  (S0582)  Completed 
    • Male Rats: Sprague Dawley; Male Mice: B6C3F1; Male Hamsters: Syrian Golden
    • Dose: 14D: HAMSTERS 1500, 3000, 6000, 12000 OR 24000; 90D: RATS 10, 100, 1000, 8000 OR 16000 PPM; MICE 10, 100, 1000, 4000 OR 8000 PPM; HAMSTERS 100, 1000, 6000, 12000, 24000 ppm.
  • Toxicokinetic Study (Gavage; Intravenous)  (S0637)  Completed 
    • Citation: Dix KJ, Coleman DP, Jeffcoat AR. Comparative metabolism and disposition of gemfibrozil in male and female Sprague-Dawley rats and Syrian golden hamsters. Drug Metab Dispos. 1999 Jan;27(1):138-46.Pubmed Abstract
    • Citation: Thomas BF, Burgess JP, Coleman DP, Scheffler NM, Jeffcoat AR, Dix KJ. Isolation and identification of novel metabolites of gemfibrozil in rat urine. Drug Metab Dispos. 1999 Jan;27(1):147-57.Pubmed Abstract
    • Male and Female Rats: Sprague Dawley; Male and Female Hamsters: Syrian Golden; Rats: Sprague Dawley; Male and Female Hamsters: Syrian Golden
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