National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-m930066

Testing Status of Gemfibrozil - M930066

 

CASRN: 25812-30-0

Related: PEROXISOME PROJECT (GEMFIBROZIL)

Formula: C15-H22-O3

Synonyms/Common Names

  • 5-(2,5-dimethylphenoxy)-2,2-dimethyl pentanoic acid

Known Uses

Serum lipid regulating agent (antohyperlipoproteinemic)

Chemical Properties

Toxicity Effects (HSDB)

Special Studies

  • Toxicokinetic Study (Gavage; Intravenous)  (S0541)  Completed 
    • Citation: Toxicokinetic Study Report. The Toxicokinetics of Gemfibrozil. The Toxicokinetics of Gemfibrozil when Administered in Feed to Male Wistar Furth Rats, Syrian Hamsters and B6C3F1 Mice. The Toxicokinetics of Gemfibrozil in Male Sprague Dawley Rats, Syrian Hamsters and B6C3F1. August 29, 1995.
    • Male Rats: Sprague Dawley; Male Mice: B6C3F1; Male Hamsters: Syrian Golden; Male Rats: Sprague Dawley; Male Mice: B6C3F1; Male Hamsters: Syrian Golden
  • Toxicokinetic Study (Dosed-Feed)  (S0582)  Completed 
    • Male Rats: Sprague Dawley; Male Mice: B6C3F1; Male Hamsters: Syrian Golden
  • Toxicokinetic Study (Gavage; Intravenous)  (S0637)  Completed 
    • Citation: Dix KJ, Coleman DP, Jeffcoat AR. Comparative metabolism and disposition of gemfibrozil in male and female Sprague-Dawley rats and Syrian golden hamsters. Drug Metab Dispos. 1999 Jan;27(1):138-46.Pubmed Abstract
    • Citation: Thomas BF, Burgess JP, Coleman DP, Scheffler NM, Jeffcoat AR, Dix KJ. Isolation and identification of novel metabolites of gemfibrozil in rat urine. Drug Metab Dispos. 1999 Jan;27(1):147-57.Pubmed Abstract
    • Male and Female Rats: Sprague Dawley; Male and Female Hamsters: Syrian Golden; Rats: Sprague Dawley; Male and Female Hamsters: Syrian Golden
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.