National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-m930068

Testing Status of Peroxisome project (Dibutyl phthalate) - M930068

 

CASRN: 84-74-2

Related: DIBUTYL PHTHALATE

Formula: C16-H22-O4

Synonyms/Common Names

  • 1,2-Benzenedicarboxylic acid, 1,2-dibutyl ester
  • Dibutyl phthalate (Peroxisome project)

Known Uses

Insect repellant for impregnation of clothing; plasticizer; solvent; textile lubricant. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 2 weeks (Dosed-Feed)  (C93027A)  Completed 
    • Hamsters: Syrian Golden
    • Dose: HAMSTERS (MALES ONLY): 0, 1000, 2500, 5000, 10000 OR 20000 PPM; 5/GROUP.
  • 13 weeks (Dosed-Feed)  (C93027A)  Completed 
    • Rats: Harlan Sprague-Dawley; Mice: B6C3F1; Hamsters: Syrian Golden
    • Dose: RATS & MICE (MALES ONLY): 0, 1000, 2500, 5000, 10000 OR 20000 PPM; 10/GROUP HAMSTERS: 0, 1000, 2500, 5000, 10000, OR 20000 PPM; 10/GROUP.

Special Studies

  • Absorption Disposition Metabolism Elimination (in-vitro)  (S0847)  Completed 
    • Citation: Final Report Chemical Disposition in Mammals. 03/15/98 - 06/30/99.
    • Human (Cell Lines)

Bioassay

  • 13 weeks Subchronic Special (Dosed-Feed)  (C93027A)  Completed 
    • Rats: Harlan Sprague-Dawley; Mice: B6C3F1; Hamsters: Syrian Golden
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