National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-m930069

Testing Status of Peroxisome project (Gemfibrozil) - M930069

 

CASRN: 25812-30-0

Related: GEMFIBROZIL

Formula: C15-H22-O3

Synonyms/Common Names

  • Gemfibrozil (Peroxisome project)
  • Pentanoic acid, 5-(2,5-dimethylphenoxy)-2,2-dimethyl-

Known Uses

Lipid-regulating agent, which lowers, elevated serum lipids primarily by decreasing serum triglycerides.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 2 weeks (Dosed-Feed)  (C93027B)  Completed 
    • Hamsters: Syrian Golden
    • Dose: HAMSTERS (MALES ONLY): 0, 1500, 3000, 6000, 12000, OR 24000 PPM; 5/GROUP.
  • 13 weeks (Dosed-Feed)  (C93027B)  Completed 
    • Rats: Harlan Sprague-Dawley; Mice: B6C3F1; Hamsters: Syrian Golden
    • Dose: RATS (MALES ONLY): 0, 10, 100, 1000, 8000, OR 16000 PPM; 10/GROUP MICE (MALES ONLY): 0, 10, 100, 1000, 4000, OR 8000 PPM; 10/GROUP HAMSTERS (MALES ONLY): 0, 100, 1000, 6000, 12000, OR 24000 PPM; 10/GROUP.

Special Studies

  • Absorption Disposition Metabolism Elimination (in-vitro)  (S0849)  Completed 
    • Citation: Final Report Chemical Disposition in Mammals. 03/15/98 - 06/30/99.
    • Human (Cell Lines)
    • Dose: 1 mM.

Bioassay

  • 13 weeks Subchronic Special (Dosed-Feed)  (C93027B)  Completed 
    • Rats: Harlan Sprague-Dawley; Mice: B6C3F1; Hamsters: Syrian Golden
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