National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-m930070

Testing Status of Peroxisome project (2,4-Dichlorophenoxyacetic acid) - M930070

 

CASRN: 94-75-7

Related: 2,4-DICHLOROPHENOXYACETIC ACID

Formula: C8-H6-Cl2-O3

Synonyms/Common Names

  • 2,4-D (Peroxisome project)
  • 2,4-Dichlorophenoxyacetic acid

Known Uses

Pesticide, herbicide. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 2 weeks (Dosed-Feed)  (C93027C)  Completed 
    • Hamsters: Syrian Golden
    • Dose: HAMSTERS (MALES ONLY): 0, 12, 100, 500, 1000, OR 5000 PPM; 5/GROUP.
  • 13 weeks (Dosed-Feed)  (C93027C)  Completed 
    • Rats: Harlan Sprague-Dawley; Mice: B6C3F1; Hamsters: Syrian Golden
    • Dose: RATS (MALES ONLY): 0, 17, 83, 250, 750, 1250, OR 2500 PPM; 10/GROUP MICE (MALES ONLY): 0, 12, 28, 83, 250, 700, OR 1680 PPM; 10/GROUP HAMSTERS (MALES ONLY): 0, 12, 100, 500, 1000, OR 5000 PPM; 10/GROUP.

Special Studies

  • Absorption Disposition Metabolism Elimination (in-vitro)  (S0850)  Completed 
    • Citation: Final Report Chemical Disposition in Mammals. 03/15/98 - 06/30/99.
    • Human (Cell Lines)

Bioassay

  • 13 weeks Subchronic Special (Dosed-Feed)  (C93027C)  Completed 
    • Rats: Harlan Sprague-Dawley; Mice: B6C3F1; Hamsters: Syrian Golden
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