National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-m930071

Testing Status of Peroxisome project (WY-14643) - M930071

 

CASRN: 50892-23-4

Related: (4-CHLORO-6-(2,3-XYLIDINO)-2-PYRIMIDINYLTHIO) ACETIC ACID (WY-14643)

Formula: C14-H14-Cl-N3-O2-S

Synonyms/Common Names

  • ((4-Chloro-6-((2,3-dimethylphenyl)amino)-2-pyrimidinyl)thio)acetic acid
  • WY-14643 (Peroxisome project)

Known Uses

Developed by the pharmaceutical industry to lower serum cholesterol in humans; not currently used clinically

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 2 weeks (Dosed-Feed)  (C93027D)  Completed 
    • Mice: B6C3F1; Hamsters: Syrian Golden
    • Dose: HAMSTERS (MALES ONLY): 0, 10, 100, 500, 1000, OR 5000 PPM; 5/GROUP MICE (MALES ONLY): 0, 10, 50, 100, 500, OR 1000 PPM; 5/GROUP.
  • 13 weeks (Dosed-Feed)  (C93027D)  Report Review 
    • TOX-62 (NIH Number: 08-4419)  (Tox Peer Review 09/28/2006A )
      Toxicity Studies of WY-14,643 (CASRN 50892-23-4) Administered in Feed to Sprague-Dawley Rats, B6C3F1 Mice, and Syrian Hamsters
    • Rats: Harlan Sprague-Dawley; Mice: B6C3F1; Hamsters: Syrian Golden
    • Dose: RATS & MICE (MALES ONLY): 0, 5, 10, 50, 100 AND 500 PPM; 10/GROUP HAMSTERS (MALES ONLY): 0, 5, 10, 50, 100, OR 500 PPM; 10/GROUP.

Special Studies

  • Absorption Disposition Metabolism Elimination (in-vitro)  (S0848)  Completed 
    • Citation: Final Report Chemical Disposition in Mammals. 03/15/98 - 06/30/99.
    • Human (Cell Lines)
    • Dose: 1 mM.

Bioassay

  • 13 weeks Subchronic Special (Dosed-Feed)  (C93027D)  Subchronic Toxicology Review 
    • Rats: Harlan Sprague-Dawley; Mice: B6C3F1; Hamsters: Syrian Golden
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