Skip to Main Navigation
Skip to Page Content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.


The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Testing Status of Peroxisome project (WY-14643) M930071


CASRN: 50892-23-4

Formula: C14-H14-Cl-N3-O2-S

Synonyms/Common Names

  • ((4-Chloro-6-((2,3-dimethylphenyl)amino)-2-pyrimidinyl)thio)acetic acid
  • WY-14643 (Peroxisome project)

Known Uses

Developed by the pharmaceutical industry to lower serum cholesterol in humans; not currently used clinically

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 2 weeks (Dosed-Feed)  (C93027D)  Completed 
    • Mice: B6C3F1; Hamsters: Syrian Golden
    • Dose: HAMSTERS (MALES ONLY): 0, 10, 100, 500, 1000, OR 5000 PPM; 5/GROUP MICE (MALES ONLY): 0, 10, 50, 100, 500, OR 1000 PPM; 5/GROUP.
  • 13 weeks (Dosed-Feed)  (C93027D)  Report Review 
    • Rats: Harlan Sprague-Dawley; Mice: B6C3F1; Hamsters: Syrian Golden
    • Dose: RATS & MICE (MALES ONLY): 0, 5, 10, 50, 100 AND 500 PPM; 10/GROUP HAMSTERS (MALES ONLY): 0, 5, 10, 50, 100, OR 500 PPM; 10/GROUP.

Special Studies

  • Absorption Disposition Metabolism Elimination (in-vitro)  (S0848)  Completed 
    • Citation: Final Report Chemical Disposition in Mammals. 03/15/98 - 06/30/99.
    • Human (Cell Lines)
    • Dose: 1 mM.