National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-m940010

Testing Status of o-Chloropyridine - M940010

 

CASRN: 109-09-1

Formula: C5-H4-Cl-N

Synonyms/Common Names

  • 2-Chloropyridine

Known Uses

Intermediate in synthetic organic, pharmaceutical & agricultural chemical manufacture. Used as a catalyst for phase transfer. Used in manufacture of pyrithione-based biocides for use in cosmetics & pharmaceutical products.

Chemical Properties

Toxicity Effects (HSDB)

Nomination Background

Short-Term Toxicity

  • 2 weeks (Topical Application)  (C99002)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R&M: 0, 6.25, 12.5, 25, 50, OR 100 MG/KG; 10/SEX/DOSE.
  • 13 weeks (Dosed-Water)  (C99002B)  Report Draft 
    • TOX-83 (NIH Number: 17-5945)
      Toxicity Studies of o-Chloropyridine (CASRN 109-09-1) Administered by Dosed-Water to F344/N Rats and B6C3F1 Mice
    • Rats: F344/N; Mice: B6C3F1
    • Dose: 0, 10, 30, 100, 300, or 1000 PPM; 10/sex/species.

Special Studies

  • Absorption Disposition Metabolism Elimination (Gavage; Intraperitoneal Injection; Intravenous; Topical Application)  (S0819)  Completed 
    • Citation: [14C] 2-chloropyridine: Disposition and metabolism in Fischer 344 rats and B6C3F1 mice.
    • Male Rats: F344/N; Male Mice: B6C3F1

Genetic Toxicology

  • Micronucleus  (A80857)  Completed 
    • Mice: B6C3F1
    • Male Negative 
    • Female Negative 
  • Salmonella  (A14054)  Completed 
    •  Positive 

in vitro Testing

  • Bovine Corneal Opacity and Premeability Assay (Gavage, Whole Body Exposure)  (IVT20004A)  Completed 
    • Rats/Mice: F344/N
  • Dose-Response Cytotoxicity Assay Using the EpiDermTM Skin Model (Gavage)  (IVT20004B)  Completed 
    • Mice: B6C3F1/N
  • Neutral Red Uptake Bioassay (Gavage)  (IVT20004C)  Completed 
    • Rats: Harlan Sprague-Dawley
  • Cytotoxicity Assay Using MTT Reduction in Primary Rat Hepatocytes (Dosed-Feed)  (IVT20004D)  Completed 
    • Mice: B6C3F1/NCTR BR (C57BL/6N x C3H/HEN MTV-)
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.