Testing Status of Fish project 1 (2,2-bis(Bromomethyl)-1,3-propanediol) M940074

 

CASRN: 3296-90-0

Formula: C5-H10-Br2-O2

Known Uses

BMP-used as a fire retardant in unsaturated polyester resins, in molded products, & in rigid polyurethane foam. Nitromethane-used as a rocket & engine fuel; a synthesis intermediate for agricultural fumigants, biocides, & other products; a solvent; & an explosive. TCP-used as a paint & varnish remover, solvent, & degreasing agent, & a crosslinking agent in the synthesis of polysulfides & HFP.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 1 week (Aquatic)  (C94002A)  Completed 
    • Fish: Medaka (Oryzias latipes)
    • Dose: 0, 32.4, 54, 90, 150, OR 250 MG/L; 10 FISH/DOSE/SPECIES (14-DAY-OLD FISH).
  • 1 week (Aquatic)  (C94002B)  Completed 
    • Fish: Guppy (Poecilia reticulata)
    • Dose: 0, 32.4, 54, 90, 150, OR 250 MG/L; 10 FISH/DOSE/SPECIES (14-DAY-OLD FISH).
  • 4 weeks (Aquatic)  (C94002A)  Completed 
    • Fish: Medaka (Oryzias latipes)
    • Dose: 0, 19.4, 32.4, 54, 90, OR 150 MG/L; 20 FISH/D0SE/SPECIES.
  • 4 weeks (Aquatic)  (C94002B)  Completed 
    • Fish: Guppy (Poecilia reticulata)
    • Dose: 0, 19.4, 32.4, 54, 90, OR 150 MG/L; 20 FISH/DOSE/SPECIES.

Long-Term Carcinogenicity

  • 14 months (Aquatic)  (C94002A)  Report Complete 
    • TR-528 (NIH Number: 06-4464)  (Peer Review Approval 02/18/2004A )
      Carcinogenesis Studies of 2,2-bis(Bromomethyl)-1,3-Propanediol, Nitromethane, and 1,2,3-Trichloropropane (CASRNs 3296-90-0, 75-52-5, and 96-18-4) in Guppies (Poecilia reticulata) and Medaka (Oryzias latipes) (Waterborne Studies)
    • Fish: Medaka (Oryzias latipes)
    • Carcinogenesis Results
      • Male Fish Positive 
      • Female Fish Negative 
    • Dose: Medaka: 0, 24, 60, 150 MG/L 160 FISH/DOSE/SPECIES.
  • 16 months (Aquatic)  (C94002B)  Report Complete 
    • TR-528 (NIH Number: 06-4464)  (Peer Review Approval 02/18/2004A )
      Carcinogenesis Studies of 2,2-bis(Bromomethyl)-1,3-Propanediol, Nitromethane, and 1,2,3-Trichloropropane (CASRNs 3296-90-0, 75-52-5, and 96-18-4) in Guppies (Poecilia reticulata) and Medaka (Oryzias latipes) (Waterborne Studies)
    • Fish: Guppy (Poecilia reticulata)
    • Carcinogenesis Results
      • Male Fish Positive 
      • Female F Inadequate Study 
    • Dose: Guppy: 160 FISH/DOSE/SPECIES.