Testing Status of Fish Project 1 (Nitromethane) M940075

 

CASRN: 75-52-5

Formula: C-H3-N-O2

Known Uses

BMP-used as a fire retardant in unsaturated polyester resins, in molded products, & in rigid polyurethane foam. Nitromethane-used as a rocket & engine fuel; a synthesis intermediate for agricultural fumigants, biocides, & other products; a solvent; & an explosive. TCP-used as a paint & varnish remover, solvent, & degreasing agent, & a crosslinking agent in the synthesis of polysulfides & HFP.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 1 week (Aquatic)  (C94003A)  Completed 
    • Fish: Medaka (Oryzias latipes)
    • Dose: 10 fish/dose/species (14-day-old fish).
  • 1 week (Aquatic)  (C94003B)  Completed 
    • Fish: Guppy (Poecilia reticulata)
    • Dose: 10 fish/dose/species (14-day-old fish).
  • 4 weeks (Aquatic)  (C94003A)  Completed 
    • Fish: Medaka (Oryzias latipes)
    • Dose: 0, 14.3, 23.8, 39.6, 66.0, or 110.0 mg/L; 40 fish/dose/species.
  • 4 weeks (Aquatic)  (C94003B)  Completed 
    • Fish: Guppy (Poecilia reticulata)
    • Dose: 0, 14.3, 23.8, 39.6, 66.0, or 110.0 mg/L; 40 fish/dose/species.

Long-Term Carcinogenicity

  • 13 months (Aquatic)  (C94003A)  Report Complete 
    • TR-528 (NIH Number: 06-4464)  (Peer Review Approval 02/18/2004A )
      Carcinogenesis Studies of 2,2-bis(Bromomethyl)-1,3-Propanediol, Nitromethane, and 1,2,3-Trichloropropane (CASRNs 3296-90-0, 75-52-5, and 96-18-4) in Guppies (Poecilia reticulata) and Medaka (Oryzias latipes) (Waterborne Studies)
    • Fish: Medaka (Oryzias latipes)
    • Carcinogenesis Results
      • Male Fish Negative 
      • Female Fish Negative 
    • Dose: Medaka: 9.4, 21, or 46.6 mg/L 160 fish/dose/species.
  • 16 months (Aquatic)  (C94003B)  Report Complete 
    • TR-528 (NIH Number: 06-4464)  (Peer Review Approval 02/18/2004A )
      Carcinogenesis Studies of 2,2-bis(Bromomethyl)-1,3-Propanediol, Nitromethane, and 1,2,3-Trichloropropane (CASRNs 3296-90-0, 75-52-5, and 96-18-4) in Guppies (Poecilia reticulata) and Medaka (Oryzias latipes) (Waterborne Studies)
    • Fish: Guppy (Poecilia reticulata)
    • Carcinogenesis Results
      • Female Fish Negative 
      • Male F Inadequate Study 
    • Dose: Guppy: 10.8, 30.9, or 88.4 mg/L 160 fish/dose/species.