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Testing Status of AZT + TMP/SMX (mixture) combination M940100

 

CASRN: AZTTMPSMX

Synonyms/Common Names

  • AZT + TMP/SMX (mixture) combination (AIDS)
  • AZT + Trimethoprim/Sulfamethoxazole (mixture) combination

Secondary:

  • 30516-87-1 - 3'-Azido-3'-deoxythymidine (AIDS)
  • 30516-87-1 - AZT transplacental carcinogenesis study
  • 723-46-6 - Sulfamethoxazole
  • 738-70-5 - Trimethoprim
  • TMPSMXMIXNTP - Trimethoprim/sulfamethoxazole (mixture)

Known Uses

Experimental AIDS therapy

Short-Term Toxicity

  • 13 weeks (Gavage)  (C95004B)  Completed 
    • Mice: B6C3F1
  • 13 weeks (Gavage)  (C95004)  Completed 
    • Mice: B6C3F1

Special Studies

  • Toxicokinetic Study (Gavage; Intravenous)  (S0609)  Completed 
    • Citation: 3'-Azido-3'-Deoxythymidine (AZT) + TMP/SMX. Toxicokinetic study report. The toxicokinetics of 3'-azido-3'deoxythymidine (AZT) when administered alone and in combination with trimethoprim (TMP) and sulfamethoxazole (SMX) to male and female B6C3F1 mice. February 20, 2007
    • Male and Female Mice: B6C3F1
    • Dose: Single Administration: azt (iv&gav): 15, 25, 50, 100 mg/kg; azt+tmp smx (iv): 2/5 and 1/20, (gav): 100/1000, 100/500, 100/250, 50/1000, 50/250, 25/1000, 25/250. Multiple Administration: azt+tmpsmx (gav): 100/1000, 100/500, 100/250, 50/1000, 50/250, 25/1000, 25/250.. Single Administration: azt (iv&gav): 15, 25, 50, 100 mg/kg; azt+tmp smx (iv): 2/5 and 1/20, (gav): 100/1000, 100/500, 100/250, 50/1000, 50/250, 25/1000, 25/250. Multiple Administration: azt+tmpsmx (gav): 100/1000, 100/500, 100/250, 50/1000, 50/250, 25/1000, 25/250..
  • Toxicokinetic Study (Gavage)  (S0610)  Completed 
    • Male and Female Mice: B6C3F1
    • Dose: AZT: 0, 50, 100, 200 mg/kg TMP/SMX: 500, 1000, 2000 mg/kg Folinic Acid: 50 mg/kg.

Organ Systems Toxicity

  • 30 days Repro/Dev Gen Tox (28-Day) (Gavage)  (RDGT95002)  Completed 
    • NIH Number: 99-3940
      Citation: NIEHS Technical Report on the Reproductive, Developmental, and General Toxicity Studies of 3'-Azido-3'-dioxythymidine (AZT), Trimethoprim (TMP)/ Sulfamethoxazole (SMX), and Folinic Acid Combinations Administered by Gavage to Swiss (CD-1®) Mice
    • Male and Female Mice: Swiss
    • Dose: Multiple.