National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-m940101

Testing Status of DL-Camphor - M940101

 

CASRN: 76-22-2

Related: D-CAMPHOR (464-49-3) AND DL-CAMPHOR (21368-68-3)

Formula: C10-H16-O

Synonyms/Common Names

  • Bicyclo(2.2.1)heptan-2-one, 1,7,7-trimethyl-
  • 2-Bornanone
  • Camphor
  • Root bark oil
  • Spirit of camphor

Known Uses

Plasticizer for cellulose esters; used in manufacture of plastics; in lacquers and varnishes; in explosives; in pyrotechnics; as most repellant; in embalming fluids; as preservative in pharmaceuticals and cosmetics. Topical anti-infective. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 2 weeks (Topical Application)  (C87003)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R: 0, 16, 32, 64, 125, OR 250 MG/KG M: 0, 200, 400, 600, 800, OR 1000 MG/KG; 5/SEX/SPECIES/GROUP.
  • 13 weeks (Topical Application)  (C87003)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R: 0, 16, 32, 64, 125, OR 250 MG/KG M: 0, 200, 400, 600, 800, OR 1000 MG/KG; 10/SEX/SPECIES/GROUP.

Special Studies

  • Toxicokinetic Study (Intravenous; Topical Application)  (S0555)  Completed 
    • Citation: The Toxicokinetics of Intravenously and Dermally Administered d,l-Camphor (CAM) in male and female B6C3F1 mice and F344 rats. November 27, 1996
    • Male and Female Rats: F344/N; Male and Female Mice: B6C3F1; Male and Female Rats: F344/N; Male and Female Mice: B6C3F1
    • Dose: Dermal: mice: SA(unprotect):500; (protect):200, 500, 1000; rats: SA(unprotect):200; (protect): 50, 200, 400; mice: Repeated Ad(unprotect): 500; rats: Repeated Ad(unprotect): 200 IV:mice:SA: 50; rats:SA: 6 all doses are mg/kg body weight.

Genetic Toxicology

  • Micronucleus  (A69097)  Completed 
    • Mice: B6C3F1
    • Male Negative 
    • Female Negative 
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.