Testing Status of AZT + Pyrimethamine combination (AIDS) M940116

 

CASRN: AZT/PYRIMETH

Secondary:

  • 30516-87-1 - 3'-Azido-3'-deoxythymidine (AIDS)
  • 30516-87-1 - AZT transplacental carcinogenesis study
  • 58-14-0 - Pyrimethamine

Known Uses

Aids therapeutic

Organ Systems Toxicity

  • 14 days Immunotoxicity (Gavage)  (IMM94007)  Completed 
    • Female Mice: B6C3F1
    • Dose: PYM: (2.5, 5.0, OR 10.0 MG/KG + 200 MG/KG AZT) PYM: 10 MG/KG AZT: 200 MG/KG CYCLOPHOSPHAMIDE 25 MG/KG X 4.
  • 28 days Immunotoxicity (Gavage)  (IMM96013)  Completed 
    • Female Mice: B6C3F1
    • Dose: AZT: (50, 100, OR 200 MG/KG + 10 MG/KG PYM) AZT: 200 MG/KG PYM: 10 MG/KG.