National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-m940150

Testing Status of Bisphenol S - M940150

 

CASRN: 80-09-1

Formula: C12-H10-O4-S

Synonyms/Common Names

  • Bis(4-hydroxyphenyl)sulfone
  • 4,4'-Bisphenol S
  • 4,4'-Dihydroxydiphenyl sulfone
  • DIPHONE
  • Phenol, 4,4'-sulfonylbis-
  • 1,1'-Sulfonylbis(4-hydroxybenzene)

Known Uses

"The use of Bisphenol S (SDP) is increasing in a variety of processes, especially as a chemical intermediate and monomer in the manufacture of plastics and resins. // Starting material/chemical intermediate, Monomer/curing agent, Monomer/property enhancer, Analytical reagent unavailable" BPS is used in plasticizers and epoxy resins and as a developer in thermal paper.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 14 days (Dosed-Feed)  (C94150)  On Test 
    • Dose Range-Finding
    • Mice: B6C3F1
    • Dose: 0, 600, 1200, 2500, or 5000 ppm; 5/sex/group.

Modified One-Generation

  • GD 6 - PND 28 Dose Range Finding (Dosed-Feed)  (MOG94150)  On Test 
    • Perinatal Dose Range-Finding Study in Bisphenol S in Dosed Feed
    • Rats: Harlan Sprague-Dawley
    • Dose: 0, 5000, 10, 000, 15, 000 or 20, 000 ppm.

Special Studies

  • Absorption Disposition Metabolism Elimination (Gavage; Intravenous)  (K94150)  Completed 
    • Male and Female Rats: Harlan Sprague-Dawley; Male and Female Mice: B6C3F1/N; Male and Female Rats: Harlan Sprague-Dawley; Male and Female Mice: B6C3F1/N
    • Dose: 50 mg/kg. 50, 150, 500 mg/kg.
  • Toxicokinetic Study (Dosed-Feed; Gavage; Intravenous)  (K94150B)  Assigned 
    • Rats: Harlan Sprague-Dawley; Mice: B6C3F1/N; Rats: Harlan Sprague-Dawley; Mice: B6C3F1/N; Rats: Harlan Sprague-Dawley; Mice: B6C3F1/N
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.