National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-m940157

Testing Status of Cumene - M940157

 

CASRN: 98-82-8

Related: CUMENE HYDROPEROXIDE (80-15-9)

Formula: C9-H12

Synonyms/Common Names

  • C9 Alkylbenzenes
  • Isopropylbenzene

Known Uses

Used in the production of phenol, acetone, and alpha-methylstyrene; solvent. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 2 weeks (Inhalation)  (C96011)  Completed 
    • Rats: F344/N; Mice: B6C3F1/N
    • Dose: R&M: 0, 250, 500, 1000, 2000, OR 4000 PPM; 5/SEX/SPECIES.
  • 13 weeks (Inhalation)  (C96011)  Completed 
    • Rats: F344/N; Mice: B6C3F1/N
    • Dose: R: 0, 62.5, 125, 250, 500, OR 1000 (20/SEX) M: 0, 62.5, 125, 250, 500, OR 1000 (10/SEX).

Long-Term Carcinogenicity

  • 2 years (Inhalation)  (C96011)  Report Complete 
    • TR-542 (NIH Number: 09-5885)  (Peer Review Approval 05/16/2007A )
      Toxicology and Carcinogenesis Studies of Cumene (CASRN 98-82-8) in F344/N Rats and B6C3F1 Mice (Inhalation Studies)
    • Rats: F344/N; Mice: B6C3F1/N
    • Carcinogenesis Results
      • Male Rats Clear Evidence 
      • Female Rats Some Evidence 
      • Male Mice Clear Evidence 
      • Female Mice Clear Evidence 
    • Dose: R: 0, 250, 500, OR 1000 PPM MM: 0, 250, 500, OR 1000 PPM FM: 0, 125, 250, OR 500 PPM 50/SEX/SPECIES.

Special Studies

  • Absorption Disposition Metabolism Elimination (Gavage)  (S0972)  Completed 
    • Citation: Disposition of Cumene in Rats and Mice after Oral and Intravenous Administration.
    • Male Rats: Fischer 344; Male and Female Mice: B6C3F1
    • Dose: 10-1000 mg/kg.

Genetic Toxicology

  • Comet Assay  (G1104ZE)  Completed 
    • Rats
  • Comet Assay  (G1104ZF)  Completed 
    • Mice
  • Micronucleus  (A60520)  Completed 
    • Mice: B6C3F1
    • Male Negative 
    • Female Negative 
  • Micronucleus  (A98265)  Completed 
    • Rats: Fischer 344
    • Male Positive 
  • Micronucleus  (G1104ZC)  Completed 
    • Rats: Fischer 344
    • Male Negative 
  • Micronucleus  (G1104ZD)  Completed 
    • Mice: B6C3F1
    • Male Negative 
    • Female Negative 
  • Salmonella  (A42965)  Completed 
    •  Negative 
  • Salmonella  (G1104ZB)  Completed 
    •  Negative 

Toxicogenomics

  • Microarray Analysis (Dosed-Feed) Selected (T94157)  
    • Rats: Harlan Sprague-Dawley
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