National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-m950074

Testing Status of Carbonyl sulfide - M950074

 

CASRN: 463-58-1

Formula: C-O-S

Synonyms/Common Names

  • Carbon monoxide monosulfide
  • Carbon oxide sulfide
  • Oxycarbon sulfide

Known Uses

Synthesis of thio organic compounds; intermediate for alkyl carbonates and organic sulfur compounds. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

Chemical Properties

Toxicity Effects (HSDB)

Special Studies

  • Toxicokinetic Study (Gavage; Inhalation)  (S0655)  Completed 
    • Male Rats: F344/N; Male Mice: B6C3F1; Male Rats: F344/N; Male Mice: B6C3F1

Genetic Toxicology

  • Salmonella  (A35125)  Completed 
    •  Weakly Positive 

Organ Systems Toxicity

  • 2 weeks Neurotoxicology Assessment (Inhalation)  (NTA20001)  Completed 
    • Male and Female Rats: F344/N
    • Dose: 0, 300, 400, OR 500 PPM.
  • 12 weeks Neurotoxicology Assessment (Inhalation)  (NTA20002)  Completed 
    • Male and Female Rats: F344/N
    • Dose: 0, 200, 300, OR 400 PPM.
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