Testing Status of Transgenic model evaluation (DES) M950080

 

CASRN: 56-53-1

Formula: C18-H20-O2

Synonyms/Common Names

  • DES (Transgenic model evaluation)
  • Diethylstilbestrol (Transgenic model evaluation)

Known Uses

Chemotherapeutic, synthetic estrogen used to prevent abortions, growth promoter for livestock (Merck 1989). Evaluation of Tg.AC and p53+/- transgenic mice models to identify chemicals for carcinogenic potential

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 2 weeks (Topical Application)  (C97011G)  Completed 
    • Mice: FVB/N
    • Dose: 0, 30, 60, 120, 180, OR 240 UG/KG; 5/SEX/DOSE; 2X/WEEK.
  • 2 weeks (Gavage)  (C97011H)  Completed 
    • Mice: FVB/N
    • Dose: 0, 30, 60, 120, 180, OR 240 UG/KG; 5/SEX/DOSE; 2X/WEEK.
  • 24 weeks (Topical Application)  (C95007A)  Completed 
    • Mice: Tg.AC (FVB/N) Hemizygous
    • Dose: 0 OR 0.83 MG/KG; 15/SEX/DOSE -- 2 TIMES PER WEEK.
  • 25 weeks (Subcutaneous Injection)  (C95007B)  Completed 
    • Mice: P53 +/- (C57BL/6)
    • Dose: 0 OR 1000 UG/KG; 15/SEX/DOSE -- 2 TIMES PER WEEK.
  • 26 weeks (Topical Application)  (C97011G)  Completed 
    • Mice: FVB/N; Mice: Tg.AC (FVB/N) Homozygous
    • Dose: TG.AC MICE AT 0, 30, 240, OR 480 UG/KG AND FVB MICE AT 0 OR 480 UG/KG; 15/SEX/DOSE; 2X/WEEK.
  • 26 weeks (Gavage)  (C97011H)  Completed 
    • Mice: FVB/N; Mice: Tg.AC (FVB/N) Homozygous
    • Dose: TG.AC MICE AT 0, 30, 240, OR 480 UG/KG AND FVB MICE AT 0 AND 480 UG/KG; 15/SEX/DOSE; 2X/WEEK.