National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-m950081

Testing Status of Transgenic model evaluation (Cyclosporin A) - M950081

 

CASRN: 59865-13-3

Formula: C62-H111-N11-O12

Synonyms/Common Names

  • Cyclosporin A (Transgenic model evaluation)
  • (R-(R*,R*-(E)))-Cyclic(L-alanyl-D-alanyl-N-methyl-L-leucyl-N-methyl-L-leucyl-N-methyl-L-valyl-3-hydroxy-N,4-dimethyl-L-2-amino-6-octenoyl-L-alpha-aminobutyryl-N-methylglycyl-N-methyl-L-leucyl-L-valyl-N-methyl-L-leucyl)

Known Uses

Immunosuppressive, drug occurring naturally in fungus

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 25 weeks (Gavage)  (C95007C)  Completed 
    • Mice: Tg.AC (FVB/N) Hemizygous
    • Dose: 0, 10, OR 25 MG/KG; 15/SEX/DOSE -- 5 TIMES PER WEEK.
  • 25 weeks (Gavage)  (C95007D)  Completed 
    • Mice: P53 +/- (C57BL/6)
    • Dose: 0, 10, OR 25 MG/KG; 15/SEX/DOSE -- 5 TIMES PER WEEK.
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.