Testing Status of Transgenic model evaluation (Melphalan) M950082

 

CASRN: 148-82-3

Formula: C13-H18-Cl2-N2-O2

Synonyms/Common Names

  • Melphalan (Transgenic model evaluation)
  • 3-(p-(Bis(2-chloroethyl)amino)phenyl)-L-alanine

Known Uses

Chemotherapeutic used to treat multiple myeloma, cancer of the ovary. The objective of this study is to evaluate the Tg.AC and p53+/- transgenic mice models to identify chemicals for carcinogenic potential.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 2 weeks (Topical Application)  (C97011C)  Completed 
    • Mice: Tg.AC (FVB/N) Homozygous
    • Dose: MICE ONLY: 0, 0.25, 0.5, 1, 2, OR 4 MG/KG; 5/SEX -- 1X/WEEK.
  • 2 weeks (Gavage)  (C97011D)  Completed 
    • Mice: Tg.AC (FVB/N) Homozygous
    • Dose: MICE ONLY: 0, 0.25, 0.5, 1, 2, OR 4 MG/KG; 5/SEX -- 1X/WEEK.
  • 4 weeks (Gavage)  (C97011M)  Completed 
    • Mice: FVB/N
    • Dose: 1.0, 2.0, 4.0, 8.0 OR 16.0 MG/KG; 10/SEX/DOSE; 1X/WEEK.
  • 24 weeks (Topical Application)  (C95007E)  Completed 
    • Mice: Tg.AC (FVB/N) Hemizygous
    • Dose: 0, 8.3, OR 25 MG/KG; 15/SEX/DOSE -- 1 TIME PER WEEK.
  • 24 weeks (Intraperitoneal Injection)  (C95007F)  Completed 
    • Mice: P53 +/- (C57BL/6)
    • Dose: 0, 0.3, OR 1.5 MG/KG; 15/SEX/DOSE -- 3 TIMES PER WEEK.
  • 26 weeks (Topical Application)  (C97011C)  Subchronic Toxicology Review 
    • Mice: FVB/N; Mice: Tg.AC (FVB/N) Homozygous
    • Dose: MICE ONLY: 0.25, 1, OR 4 MG/KG, 15/SEX/DOSE; CONTROLS - VEHICLE ONLY, 15/SEX; FVB/N: 0 OR 4 MG/KG, 15/DOSE -- 1X WEEK TPA - POSITIVE CONTROL - 1.25 UG TPA 3X/WEEK (IN A VOLUME UP TO 100 UL).
  • 26 weeks (Gavage)  (C97011D)  Completed 
    • Mice: FVB/N; Mice: Tg.AC (FVB/N) Homozygous
    • Dose: MICE ONLY: 0.25, 1, OR 4 MG/KG, 15/SEX/DOSE; CONTROLS - VEHICLE ONLY, 15/SEX; FVB/N: 0 OR 4 MG/KG, 15/DOSE -- 1X WEEK TPA - POSITIVE CONTROL - 1.25 UG TPA 3X/WEEK (IN A VOLUME UP TO 100 UL).