Testing Status of Transgenic model evaluation (8-Hydroxyquinoline) M950085

 

CASRN: 148-24-3

Formula: C9-H7-N-O

Synonyms/Common Names

  • 8-Hydroxyquinoline (Transgenic model evaluation)
  • 8-Quinolinol

Known Uses

Reagent, antimicrobial, preservative, chemical intermediate. The objective of this study is to evaluate the Tg.AC and p53+/- transgenic mice models to identify chemicals for carcinogenic potential.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 24 weeks (Topical Application)  (C95007K)  Completed 
    • Mice: Tg.AC (FVB/N) Hemizygous
    • Dose: 0 OR 450 MG/KG; 15 (30 CONTROLS)/SEX/DOSE -- 5 TIMES PER WEEK.
  • 24 weeks (Dosed-Feed)  (C95007L)  Completed 
    • Mice: P53 +/- (C57BL/6)
    • Dose: 0 OR 3000 PPM; 15 (30 CONTROLS)/SEX/DOSE.