National Toxicology Program

National Toxicology Program

Testing Status of Transgenic model evaluation (Rotenone) - M950086


CASRN: 83-79-4

Formula: C23-H22-O6

Synonyms/Common Names

  • (2R-(2-alpha,6Aalpha,12Aalpha))-1,2,12,12A-Tetrahydro-8,9-dimethoxy-2-(1-methylethenyl)-(1)benzopyrano(3,4-b)furo(2,3-h)(1)benzopyran-6(6aH)-one (9CI)
  • Rotenone (Transgenic model evaluation)

Known Uses

Fish poison, medical antiprotozoal, insecticide on fruits, livestock, vegetables, forage crops, occurs naturally in certain roots.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 24 weeks (Topical Application)  (C95007M)  Completed 
    • Mice: Tg.AC (FVB/N) Hemizygous
    • Dose: 0 OR 166 MG/KG; 15 (30 CONTROLS)/SEX/DOSE -- 5 TIMES PER WEEK.
  • 24 weeks (Dosed-Feed)  (C95007N)  Completed 
    • Mice: P53 +/- (C57BL/6)
    • Dose: 0 OR 1200 PPM; 15 (30 C0NTROLS)/SEX/DOSE.
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.