National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-m950087

Testing Status of Transgenic Model Evaluation (2,3,7,8-Tetrachlorodibenzodioxin) - M950087

 

CASRN: 1746-01-6

Formula: C12-H4-Cl4-O2

Synonyms/Common Names

  • TCDD
  • 2,3,7,8-Tetrachlorodibenzo(b,e)(1,4)dioxin (9CI)
  • 2,3,7,8-Tetrachlorodibenzo-1,4-dioxin
  • 2,3,7,8-Tetrachlorodibenzodioxin (Transgenic model evaluation)

Known Uses

Herbicide & fungicide (i.e.2,4,5-t & pentachlorophenols); tested for use in flameproofing polyesters & against insects & wood-destroying fungi; contamination created in manufacture of agent orange.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 25 weeks (Topical Application)  (C95007O)  Completed 
    • Mice: Tg.AC (FVB/N) Hemizygous
    • Dose: 0 OR 0.166 UG/KG; 15/SEX/DOSE -- 3 TIMES PER WEEK.
  • 25 weeks (Gavage)  (C95007P)  Completed 
    • Mice: P53 +/- (C57BL/6)
    • Dose: M: 0 OR 0.25 UG/KG F: 0 OR 1.0 UG/KG; 15/SEX/DOSE -- 2 TIMES PER WEEK.
  • 26 weeks (Gavage)  (C97012A)  Completed 
    • Mice: Tg.AC (FVB/N) Hemizygous
    • Dose: FM: 0, 105, 450, OR 1250 NG/KG/DAY; 20/DOSE (5 DAYS PER WEEK).
  • 26 weeks (Topical Application)  (C97012B)  Completed 
    • Mice: Tg.AC (FVB/N) Hemizygous
    • Dose: FM: 0, 5, 17, 36, 76, 121, 166, 355, OR 760 NG/KG; 20/DOSE (3X PER WEEK).
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.