Testing Status of Transgenic model evaluation (2,4-Diaminotoluene) M950089

 

CASRN: 95-80-7

Formula: C7-H10-N2

Synonyms/Common Names

  • 2,4-Diaminotoluene (Transgenic model evaluation)
  • 4-Methyl-1,3-benzenediamine (9CI)
  • 2,4-Toluene diamine

Known Uses

Intermediate for polyurethanes and dyes; in hair dyes (formerly). The objective of this study is to evaluate the Tg.AC and p53+/- transgenic mice models to identify chemicals for carcinogenic potential.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 25 weeks (Topical Application)  (C95007R)  Completed 
    • Mice: Tg.AC (FVB/N) Hemizygous
    • Dose: 0 OR 30 MG/KG; 15/SEX/DOSE -- 5 TIMES PER WEEK.
  • 24 weeks (Dosed-Feed)  (C95007S)  Completed 
    • Mice: P53 +/- (C57BL/6)
    • Dose: 0 OR 200 PPM; 15 (30 CONTROLS)/SEX/DOSE.