http://ntp.niehs.nih.gov/go/ts-m950090
Testing Status of Transgenic model evaluation (2,6-Diaminotoluene 2HCl) - M950090
CASRN:
15481-70-6
Formula:
C7-H10-N2.2Cl-H
Synonyms/Common Names
- 1,3-Benzenediamine, 2-methyl-, dihydrochloride (9CI)
- 2,6-Diaminotoluene dihydrochloride
- 2,6-Diaminotoluene HCL (Transgenic model evaluation)
Known Uses
Intermediate for dyes, polyurethane foams, and elastomers; feed. The objective of this study is to evaluate the tg.ac and p53+/- transgenic mice models to identify chemicals for carcinogenic potential.
- 24 weeks (Topical Application)
(C95007T)
Completed
- Mice: Tg.AC (FVB/N) Hemizygous
- Dose: 0 OR 30 MG/KG; 15/SEX/DOSE -- 5 TIMES PER WEEK.
- 24 weeks (Dosed-Feed)
(C95007U)
Completed
- Mice: P53 +/- (C57BL/6)
- Dose: 0 OR 200 PPM; 15 (30 CONTROLS)/SEX/DOSE.
