Testing Status of Transgenic model evaluation (2,6-Diaminotoluene 2HCl) M950090

 

CASRN: 15481-70-6

Formula: C7-H10-N2.2Cl-H

Synonyms/Common Names

  • 1,3-Benzenediamine, 2-methyl-, dihydrochloride (9CI)
  • 2,6-Diaminotoluene dihydrochloride
  • 2,6-Diaminotoluene HCL (Transgenic model evaluation)

Known Uses

Intermediate for dyes, polyurethane foams, and elastomers; feed. The objective of this study is to evaluate the tg.ac and p53+/- transgenic mice models to identify chemicals for carcinogenic potential.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 24 weeks (Topical Application)  (C95007T)  Completed 
    • Mice: Tg.AC (FVB/N) Hemizygous
    • Dose: 0 OR 30 MG/KG; 15/SEX/DOSE -- 5 TIMES PER WEEK.
  • 24 weeks (Dosed-Feed)  (C95007U)  Completed 
    • Mice: P53 +/- (C57BL/6)
    • Dose: 0 OR 200 PPM; 15 (30 CONTROLS)/SEX/DOSE.