National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-m950093

Testing Status of Allyl bromide - M950093

 

CASRN: 106-95-6

Formula: C3-H5-Br

Synonyms/Common Names

  • AB
  • 3-Bromopropene
  • 3-Bromopropylene
  • 1-Propene, 3-bromo-
  • 2-Propenyl bromide

Known Uses

Starting material/chemical intermediate in organic synthesis & intermediate in the manufacture of polymers/resins, synthetic perfumes, pharmaceuticals, agricultural chemicals, and other allyl compounds.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 2 weeks (Topical Application)  (C96003B)  Completed 
    • Mice: FVB/N
    • Dose: 0, 7.5, 15, 30, 60 OR 120 MG/KG; 5/SEX/DOSE; 5X/WEEK.
  • 2 weeks (Gavage)  (C96003)  Completed 
    • Mice: C57BL/6
    • Dose: 0, 7.5, 15, 30, 60, OR 120 MG/KG; 5/SEX/DOSE; 5X/WEEK.
  • 40 weeks (Gavage)  (C96003C)  Subchronic Toxicology Review 
    • GMM-07 (NIH Number: 08-4424)  (Peer Review Approval 08/28/2006A )
      Toxicology Studies of Allyl Bromide (CASRN 106-95-6) in Genetically Modified (FVB Tg.AC Hemizygous) Mice and Carcinogenicity Studies of Allyl Bromide in Genetically Modified [B6.129-Trp53tm1Brd (N5) Haploinsufficient] Mice (Dermal and Gavage Studies)
    • Mice: FVB/N; Mice: Tg.AC (FVB/N) Hemizygous
    • Dose: TG.AC: 0, 0.5, 1, 2, 4, OR 8 MG/KG; 15/SEX/DOSE FVB/N: 0 OR 8 MG/KG; 15/SEX/DOSE.
  • 40 weeks (Gavage)  (C96003)  Completed 
    • GMM-07 (NIH Number: 08-4424)  (Peer Review Approval 08/28/2006A )
      Toxicology Studies of Allyl Bromide (CASRN 106-95-6) in Genetically Modified (FVB Tg.AC Hemizygous) Mice and Carcinogenicity Studies of Allyl Bromide in Genetically Modified [B6.129-Trp53tm1Brd (N5) Haploinsufficient] Mice (Dermal and Gavage Studies)
    • Mice: C57BL/6; Mice: P53 +/- (C57BL/6)
    • Dose: P53: 0, 0.5, 1, 2, 4 OR 8 MG/KG; 15/SEX/DOSE C57BL/6: 0 OR 8 MG/KG; 15/SEX/DOSE.

Special Studies

  • Toxicokinetic Study (in-vitro)  (S0667)  Completed 
    • Rats: F344/N

Genetic Toxicology

  • Micronucleus  (A03068)  Completed 
    • Mice: Tg.AC
    • Male Negative 
    • Female Negative 
  • Micronucleus  (A27120)  Completed 
    • Mice: FVB/N
    • Male Negative 
    • Female Negative 
  • Micronucleus  (A43640)  Completed 
    • Mice: P53 +/- (C57BL/6)
    • Male Negative 
    • Female Negative 
  • Micronucleus  (A87628)  Completed 
    • Mice: C57BL/6
    • Male Negative 
    • Female Negative 
  • Salmonella  (A92510)  Completed 
    •  Positive 
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.