National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-m950094

Testing Status of Dimethylaminopropyl chloride, hydrochloride - M950094

 

CASRN: 5407-04-5

Formula: C5-H12-Cl-N.Cl-H

Synonyms/Common Names

  • 3-Chloro-N,N-dimethyl-1-propylamine hydrochloride
  • 3-Chloropropyldimethyl-Ammonium Chloride
  • 3-Dimethylamino-1-Propylchloride Hydrochloride
  • DMPC
  • N-(3-Chloropropyl)-N,N-dimethylammonium chloride
  • 1-Propanamine, 3-chloro-N,N-dimethyl-, hydrochloride

Known Uses

Used as industrial & research organic chemical intermediate; pharmaceutical, agricultural, photographic intermediate; biochemical reagent for enzyme & other studies.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 2 weeks (Gavage)  (C96006)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: 0, 6.25, 12.5, 25, 50, OR 100 MG/KG; 5 ANIMALS/SEX/DOSE.
  • 13 weeks (Gavage)  (C96006B)  Report Review 
    • TOX-75 (NIH Number: 07-5965)  (Tox Peer Review 05/26/2006A )
      Toxicity Studies of Dimethylaminopropyl Chloride, Hydrochloride (CASRN 5407-04-5) Administered by Gavage to F344/N Rats and B6C3F1 Mice
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R&M: 0, 6.25, 12.5, 25, 50, OR 100 MG/KG; 10 ANIMALS/SEX/DOSE.
  • 13 weeks (Gavage)  (C96006)  Terminated 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: RATS: 0, 100, 200, 400, 800, OR 1000 MG/KG; MICE: 0, 50, 100, 200, 400, OR 800 MG/KG.

Genetic Toxicology

  • Micronucleus  (A80927)  Completed 
    • Mice: B6C3F1
    • Male Negative 
    • Female Negative 
  • Salmonella  (A71860)  Completed 
    •  Positive 
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.