Testing Status of Fish project 1 (1,2,3-Trichloropropane) M950098

 

CASRN: 96-18-4

Formula: C3-H5-Cl3

Synonyms/Common Names

  • 1,2,3-Trichloropropane

Known Uses

BMP-used as a fire retardant in unsaturated polyester resins, in molded products, & in rigid polyurethane foam. Nitromethane-used as a rocket & engine fuel; a synthesis intermediate for agricultural fumigants, biocides, & other products; a solvent; & an explosive. TCP-used as a paint & varnish remover, solvent, & degreasing agent, & a crosslinking agent in the synthesis of polysulfides & HFP.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 1 week (Aquatic)  (C95008A)  Completed 
    • Fish: Medaka (Oryzias latipes)
    • Dose: 0, 10.4, 17.4, 29, 48, OR 80 MG/L.
  • 1 week (Aquatic)  (C95008B)  Completed 
    • Fish: Guppy (Poecilia reticulata)
    • Dose: 0, 10.4, 17.4, 29, 48, OR 80 MG/L.
  • 4 weeks (Aquatic)  (C95008A)  Completed 
    • Fish: Medaka (Oryzias latipes)
    • Dose: 0, 6.5, 10.8, 18, 30, OR 50 MG/L.
  • 4 weeks (Aquatic)  (C95008B)  Completed 
    • Fish: Guppy (Poecilia reticulata)
    • Dose: 0, 6.5, 10.8, 18, 30, OR 50 MG/L.

Long-Term Carcinogenicity

  • 13 months (Aquatic)  (C95008A)  Report Complete 
    • TR-528 (NIH Number: 06-4464)  (Peer Review Approval 02/18/2004A )
      Carcinogenesis Studies of 2,2-bis(Bromomethyl)-1,3-Propanediol, Nitromethane, and 1,2,3-Trichloropropane (CASRNs 3296-90-0, 75-52-5, and 96-18-4) in Guppies (Poecilia reticulata) and Medaka (Oryzias latipes) (Waterborne Studies)
    • Fish: Medaka (Oryzias latipes)
    • Carcinogenesis Results
      • Male Fish Positive 
      • Female Fish Positive 
    • Dose: Medaka: 0, 4.5, 9, OR 18 MG/L (2 REPLICATES PER TREATMENT GROUP) 170 FISH/EACH REPLICATE AQUARIUM.
  • 16 months (Aquatic)  (C95008B)  Report Complete 
    • TR-528 (NIH Number: 06-4464)  (Peer Review Approval 02/18/2004A )
      Carcinogenesis Studies of 2,2-bis(Bromomethyl)-1,3-Propanediol, Nitromethane, and 1,2,3-Trichloropropane (CASRNs 3296-90-0, 75-52-5, and 96-18-4) in Guppies (Poecilia reticulata) and Medaka (Oryzias latipes) (Waterborne Studies)
    • Fish: Guppy (Poecilia reticulata)
    • Carcinogenesis Results
      • Male Fish Positive 
      • Female Fish Positive 
    • Dose: Guppy: 0, 4.5, 9, OR 18 MG/L (2 REPLICATES PER TREATMENT GROUP) 170 FISH/EACH REPLICATE AQUARIUM.