Skip to Main Navigation
Skip to Page Content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Testing Status of 3,3,4,4,5-Pentachlorobiphenyl (PCB 126) M950120

 

CASRN: 57465-28-8

Formula: C12-H5-Cl5

Synonyms/Common Names

  • 1,1'-Biphenyl, 3,3',4,4',5-pentachloro- (9CI)
  • PCB 126

Known Uses

Dielectric medium in transformers

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • GD 6 to PND 21 (Gavage)  (C95120)  Completed 
    • In Utero-PND 22 Exposure to PCB126
    • Citation: Mutlu E, Gao L, Collins LB, Walker NJ, Hartwell HJ, Olson JR, Sun W, Gold A, Ball LM, Swenberg JA. Polychlorinated biphenyls induce oxidative DNA adducts in female Sprague-Dawley rats. Chem Res Toxicol. 2016 Aug;29(8):1335-1344
    • Rats: Wistar Han
    • Dose: 0, 10, 50, or 250 ng/kg; 10/group.

Special Studies

  • Toxicokinetic Study (Gavage)  (S0624)  Completed 
    • Citation: Amended Toxicokinetic Study Report. Single Gavage Administration Toxicokinetic Study of 3,3',4,4',5-Pentachlorobiphenyl (PCB 126) in Female Harlan Sprague-Dawley Rats. January 15, 2007
    • Male and Female Rats: Sprague Dawley
    • Dose: FEMALE RATS: 0, 3, 10, 30, 100, 300, 1000, 3000 NG/KG MALE RATS TO BE USED AS SENTINELS.

Genetic Toxicology

  • Salmonella  (G95120)  On Test 
    • Lot/Batch:  130494

Toxicogenomics

  • Microarray Analysis (Gavage)  (T95120)  Completed 
    • In Utero - PND 22 Exposure to PCB-126
    • Rats: Wistar Han
    • Dose: 0, 10, 50, or 250 ng/kg; 8 dams and 48 pups/group.