Skip to Main Navigation
Skip to Page Content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.


The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Testing Status of Transgenic model evaluation (Methylphenidate hydrochloride) M950121


CASRN: 298-59-9

Formula: C14-H19-N-O2.Cl-H

Synonyms/Common Names

  • Methylphenidate hydrochloride (Transgenic model evaluation)
  • Ritalin hydrochloride (Transgenic model evaluation)

Known Uses

Central stimulant. The objective of this study is to evaluate the Tg.AC and p53+/- transgenic mice models to identify chemicals for carcinogenic potential.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 24 weeks (Dosed-Feed)  (C95007V)  Completed 
    • Mice: P53 +/- (C57BL/6); Mice: Tg.AC (FVB/N) Hemizygous
    • Dose: 0, 50, 250, OR 500 PPM IN FEED.