Skip to Main Navigation
Skip to Page Content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Testing Status of Tamoxifen citrate M960002

 

CASRN: 54965-24-1

Formula: C26-H29-N-O.C6-H8-O7

Synonyms/Common Names

  • 2-(4-(1,2-Diphenyl-1-butenyl)phenoxy)-N,N-dimethyl-,(Z)-, 2-hydroxy-1,2,3-oropanetricarboxylate (1:1)(9CI)
  • Nolvadex
  • TMX
  • (Z)-(2-(4-(1,2-Diphenylbut-1-enyl)phenoxy)ethyl)dimethylammonium dihydrogen

Known Uses

Antiestrogenic agent used in the therapy of breast cancer

Chemical Properties

Toxicity Effects (HSDB)

Special Studies

  • Absorption Disposition Metabolism Elimination (Gavage; Intravenous)  (S0617)  Completed 
    • Female Rats: F344/N
    • Dose: SA: gav: 0.1 and 0.3 mg/kg, IV: 0.3 mg/kg RD: gav: 0.1 and 0.3 mg/kg, gav/IV (final dose only): 0.3 mg/kg.
  • Toxicokinetic Study (Gavage)  (S0598)  Completed 
    • Citation: Reproductive Toxicity of Tamoxifen Citrate (CAS No. 54965-24-1) Administered by Gavage to Sprague-Dawley Rats. August 8, 1997.
    • Male Rats: Sprague Dawley
    • Dose: iv and gavage gav: 0.01 mg/kg in dose volume 5 mL/kg.
  • Toxicokinetic Study (Gavage; Intravenous)  (S0916)  Completed 
    • Citation: Tamoxifen, Citrate Salt. Toxicokinetic Study Report. The Toxicokinetics of Tamoxifen, Citrate Salt, when Administered Orally and Intravenously to Aged Female Fischer 344 Rats. November 15, 1999.
    • Female Rats: F344/N
    • Dose: 100, 300 ug/kg ; 300 ug/kg.
  • Toxicokinetic Study (Gavage; Intravenous)  (S0917)  Completed 
    • Citation: Tamoxifen, Citrate Salt. Toxicokinetic Study Report. The Toxicokinetics of Tamoxifen, Citrate Salt, when Administered as a Single Oral or Intravenous Dose to Male and Female Sprague Dawley Rats. November 8, 2000.
    • Male and Female Rats: Sprague Dawley
    • Dose: 10, 100, 300 ug/kg ; 300 ug/kg.
  • C. elegans  (S0885)  Completed 
    • C. elegans
    • Dose: Feeding: (0, 2.5, 4, 6.3, 10, 16, 25, 40, 63, 100, 160, 250)uMRepro: (0, 2.5, 4, 6.3, 10, 16, 25, 40, 63, 100, 160, 250) uM Growth: (0, 2.5, 4, 6.3, 10, 16, 25, 40, 63, 100, 160, 250) uM.

Organ Systems Toxicity

  • 14 weeks Continuous Breeding (Legacy) (Gavage)  (RACB95003)  Completed 
    • Citation: Reproductive Toxicity of Tamoxifen Citrate (CAS #54965-24-1) Administered by Gavage to Sprague-Dawley Rats
    • Male and Female Rats: Sprague Dawley
    • Dose: 0, .003, .01, OR .03.