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Testing Status of Tamoxifen citrate M960002

 

CASRN: 54965-24-1

Formula: C26-H29-N-O.C6-H8-O7

Synonyms/Common Names

  • 2-(4-(1,2-Diphenyl-1-butenyl)phenoxy)-N,N-dimethyl-,(Z)-, 2-hydroxy-1,2,3-oropanetricarboxylate (1:1)(9CI)
  • Nolvadex
  • TMX
  • (Z)-(2-(4-(1,2-Diphenylbut-1-enyl)phenoxy)ethyl)dimethylammonium dihydrogen

Special Studies

  • Absorption Disposition Metabolism Elimination (Gavage; Intravenous)  (S0617)  Completed 
    • Female Rats: F344/N
    • Dose: SA: gav: 0.1 and 0.3 mg/kg, IV: 0.3 mg/kg RD: gav: 0.1 and 0.3 mg/kg, gav/IV (final dose only): 0.3 mg/kg.
  • Toxicokinetic Study (Gavage)  (S0598)  Completed 
    • Citation: Reproductive Toxicity of Tamoxifen Citrate (CAS No. 54965-24-1) Administered by Gavage to Sprague-Dawley Rats. August 8, 1997.
    • Male Rats: Sprague Dawley
    • Dose: iv and gavage gav: 0.01 mg/kg in dose volume 5 mL/kg.
  • Toxicokinetic Study (Gavage; Intravenous)  (S0916)  Completed 
    • Female Rats: F344/N
    • Dose: 100, 300 ug/kg ; 300 ug/kg.
  • Toxicokinetic Study (Gavage; Intravenous)  (S0917)  Completed 
    • Male and Female Rats: Sprague Dawley
    • Dose: 10, 100, 300 ug/kg ; 300 ug/kg.
  • C. elegans  (S0885)  Completed 
    • C. elegans
    • Dose: Feeding: (0, 2.5, 4, 6.3, 10, 16, 25, 40, 63, 100, 160, 250)uMRepro: (0, 2.5, 4, 6.3, 10, 16, 25, 40, 63, 100, 160, 250) uM Growth: (0, 2.5, 4, 6.3, 10, 16, 25, 40, 63, 100, 160, 250) uM.

Organ Systems Toxicity

  • 14 weeks Continuous Breeding (Legacy) (Gavage)  (RACB95003)  Completed 
    • Male and Female Rats: Sprague Dawley
    • Dose: 0, .003, .01, OR .03.