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Testing Status of Endocrine disruptor (Genistein) M960022

 

CASRN: 446-72-0

Formula: C15-H10-O5

Synonyms/Common Names

  • Genistein (Endocrine disruptor)
  • 4H-1-Benzopyran-4-one, 5,7-dihydroxy-3-(4-hydroxyphenyl)-

Known Uses

Antineoplastic agent; growth inhibitor; naturally-occurring phytoestrogen found in several plants including soy products. Nutritional and pharmaceutical applications.

Chemical Properties

Toxicity Effects (HSDB)

Long-Term Carcinogenicity

  • 2 years (Dosed-Feed)  (C99040)  Completed 
    • TR-545 (NIH Number: 08-4430)  (Peer Review Approval 06/12/2006A )
      Toxicology and Carcinogenesis Study of Genistein (CASRN 446-72-0) in Sprague-Dawley Rats (Feed Study)
    • Rats: Sprague Dawley
    • Carcinogenesis Results
      • In Utero and continuing for 2 years:
        • Male Rats = No Evidence
        • Female Rats = Some Evidence
      • In Utero and continuing for 20 weeks:
        • Male Rats = No Evidence
        • Female Rats = Equivocal Evidence
      • In Utero and continuing for Post Natal Day 21:
        • Male Rats = No Evidence
        • Female Rats = Equivocal Evidence
    • Dose: 0, 5, 100, or 500 ppm.

Organ Systems Toxicity

  • Multigenerational Screen (Dosed-Feed)  (MG96005)  Completed 
    • NIH Number: 08-4477
      Citation: Multigenerational Reproductive Toxicology Study of Genistein (CASRN 446-72-0) in Sprague-Dawley Rats (Feed Study)
    • Male and Female Rats: Sprague Dawley
    • Reproductive Dose Range Finding (On Test)
      • Days of Treatment: 28 DAYS
      • Dose: 0, 5, 25, 100, 250, 625, OR 1250 PPM
    • Immunotoxicity (On Test)
      • Days of Treatment: 4 WEEKS
      • Dose: 0, 5, 25, 100, 250, 625, OR 1250 PPM
    • Behavioral Toxicity (On Test)
      • Days of Treatment: 10 WEEKS
      • Dose: 0, 25, 250, OR 1250 PPM
    • Multigeneration Reproductive Study (F0) (On Test)
      • Days of Treatment: 20 WEEKS
      • Dose: 0, 5, 100, OR 500 PPM
    • Multigeneration Reproductive Study (F1) (On Test)
      • Days of Treatment: 20 WEEKS
      • Dose: 0, 5, 100, OR 500 PPM
    • Multigeneration Reproductive Study (F2) (On Test)
      • Days of Treatment: 20 WEEKS
      • Dose: 0, 5, 100, OR 500 PPM
    • Multigeneration Reproductive Study (F3) (On Test)
      • Days of Treatment: 20 WEEKS
      • Dose: 0, 5, 100, OR 500 PPM
    • Multigeneration Reproductive Study (F4) (On Test)
      • Days of Treatment: 20 WEEKS
      • Dose: 0, 5, 100, OR 500 PPM
    • Cancer Study (F1) (On Test)
      • Days of Treatment: 2 YEARS
      • Dose: 0, 5, 100, OR 500 PPM
    • Cancer Study (F3) (On Test)
      • Days of Treatment: 2 YEARS
      • Dose: 0, 5, 100, OR 500 PPM