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Testing Status of Leucomalachite green M960026

 

CASRN: 129-73-7

Formula: C23-H26-N2

Synonyms/Common Names

  • Benzenamine, 4,4'-phenylmethylene)Bis(N,N-dimethyl- (9CI)
  • Malachite green leuco
  • Tetramethyldiaminotriphenylmethane

Known Uses

Plant fungicide; staining bacteria; antiseptic; dyeing textiles

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 28 days (Dosed-Feed)  (C93029B)  Completed 
    • Rats: F344/N; Mice: B6C3F1/NCTR BR (C57BL/6N x C3H/HEN MTV-)
  • 4 weeks (Dosed-Feed)  (C93029)  Completed 
    •   (Peer Review Approval 02/17/2004A ) Citation: Yamashita H, Hoenerhoff MJ, Peddada SD, Sills RC, Pandiri AR. Chemical exacerbation of light-induced retinal degeneration in F344/n rats in National Toxicology Program rodent bioassays. Toxicol Pathol. 2016 Aug;44(6):892-903
    • Rats: F344/N; Mice: B6C3F1/NCTR BR (C57BL/6N x C3H/HEN MTV-)
    • Dose: 0, 96, 290, 580, OR 1160 PPM.

Long-Term Carcinogenicity

  • 2 years (Dosed-Feed)  (C93029)  Completed 
    •   (Peer Review Approval 02/17/2004A ) Citation: Yamashita H, Hoenerhoff MJ, Peddada SD, Sills RC, Pandiri AR. Chemical exacerbation of light-induced retinal degeneration in F344/n rats in National Toxicology Program rodent bioassays. Toxicol Pathol. 2016 Aug;44(6):892-903
    • TR-527 (NIH Number: 05-4463)  (Peer Review Approval 02/17/2004A )
      Toxicology and Carcinogenesis Studies of Malachite Green Chloride and Leucomalachite Green (CASRNs 569-64-2 and 129-73-7) in F344/N Rats and B6C3F1 Mice (Feed Studies)
    • Rats: F344/N; Mice: B6C3F1/NCTR BR (C57BL/6N x C3H/HEN MTV-)
    • Carcinogenesis Results
      • Male Rats Equivocal Evidence 
      • Female Rats Equivocal Evidence 
      • Female Mice Some Evidence 
    • Dose: R: 0, 91, 272, OR 543 PPM M: 0, 91, 204, OR 408 PPM.

Genetic Toxicology

  • Micronucleus  (A31156)  Completed 
    • Mice: B6C3F1
    • Male NA 
    • Female Positive